A novel mutation in SCN5A, delQKP 1507–1509, causing long QT syndrome: Role of Q1507 residue in sodium channel inactivation

2003 ◽  
Vol 35 (12) ◽  
pp. 1513-1521 ◽  
Author(s):  
D Keller
Keyword(s):  
Sodium Channel ◽  
Long Qt Syndrome ◽  
Novel Mutation ◽  
Long Qt ◽  
Channel Inactivation ◽  
Sodium Channel Inactivation ◽  
Qt Syndrome

Delayed Sodium Channel Inactivation Mimics Long QT Syndrome 3

2003 ◽  
Vol 42 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Volker Kühlkamp ◽  
Christian Mewis ◽  
Ralph Bosch ◽  
Ludger Seipel
Keyword(s):  
Sodium Channel ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Channel Inactivation ◽  
Sodium Channel Inactivation ◽  
Qt Syndrome

scholarly journals Novel deletion mutation in the cardiac sodium channel inactivation gate causes long QT syndrome

2013 ◽  
Vol 165 (2) ◽  
pp. 362-365 ◽  
Author(s):  
Nicola Detta ◽  
Giulia Frisso ◽  
Alberto Zullo ◽  
Berardo Sarubbi ◽  
Carla Cozzolino ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Long Qt Syndrome ◽  
Deletion Mutation ◽  
Long Qt ◽  
Channel Inactivation ◽  
Sodium Channel Inactivation ◽  
Cardiac Sodium Channel ◽  
Qt Syndrome

scholarly journals The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

2012 ◽  
Vol 590 (20) ◽  
pp. 5123-5139 ◽  
Author(s):  
Weihua Song ◽  
Yucheng Xiao ◽  
Hanying Chen ◽  
Nicole M. Ashpole ◽  
Andrew D. Piekarz ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Channel Inactivation ◽  
Sodium Channel Inactivation ◽  
Qt Syndrome

scholarly journals Elucidating the role of Cavin1 in drug-induced long QT syndrome (diLQTS)

2021 ◽  
Vol 13 (2) ◽  
pp. 228-229
Author(s):  
Z. Al Sayed ◽  
C. Pereira ◽  
C. Jouve ◽  
J. Hulot
Keyword(s):  
Long Qt Syndrome ◽  
Long Qt ◽  
Drug Induced ◽  
Qt Syndrome

scholarly journals Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias

Mathematics ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 1205
Author(s):  
Timur Gamilov ◽  
Philipp Kopylov ◽  
Maria Serova ◽  
Roman Syunyaev ◽  
Andrey Pikunov ◽  
...  
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Long Qt Syndrome ◽  
Premature Ventricular Contraction ◽  
Cardiac Pacing ◽  
Long Qt ◽  
Computational Evaluation ◽  
Qt Syndrome

In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias’ effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case.

scholarly journals Substitution of a conserved alanine in the domain IIIS4–S5 linker of the cardiac sodium channel causes long QT syndrome

2005 ◽  
Vol 67 (3) ◽  
pp. 459-466 ◽  
Author(s):  
J SMITS ◽  
M VELDKAMP ◽  
C BEZZINA ◽  
Z BHUIYAN ◽  
H WEDEKIND ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Cardiac Sodium Channel ◽  
Qt Syndrome

scholarly journals The role of sympathectomy in long QT syndrome

2017 ◽  
Vol 9 (9) ◽  
pp. 3394-3397 ◽  
Author(s):  
Achilleas Antonopoulos ◽  
David Lawrence ◽  
Davide Patrini ◽  
Marco Scarci ◽  
Robert George ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Long Qt ◽  
Qt Syndrome

A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation

Heart Rhythm ◽  
2008 ◽  
Vol 5 (10) ◽  
pp. 1434-1440 ◽  
Author(s):  
Begoña Benito ◽  
Ramon Brugada ◽  
Rosa Maria Perich ◽  
Eric Lizotte ◽  
Juan Cinca ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sodium Channel ◽  
Long Qt Syndrome ◽  
Long Qt ◽  
Familial Atrial Fibrillation ◽  
Qt Syndrome

The role of mexiletine in the management of long QT syndrome

2018 ◽  
Vol 51 (6) ◽  
pp. 1061-1065 ◽  
Author(s):  
Guoliang Li ◽  
Li Zhang
Keyword(s):  
Long Qt Syndrome ◽  
Long Qt ◽  
Qt Syndrome
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