Substitution of a conserved alanine in the domain IIIS4–S5 linker of the cardiac sodium channel causes long QT syndrome

J SMITS; M VELDKAMP; C BEZZINA; Z BHUIYAN; H WEDEKIND; E SCHULZEBAHR; A WILDE

doi:10.1016/j.cardiores.2005.01.017

Substitution of a conserved alanine in the domain IIIS4–S5 linker of the cardiac sodium channel causes long QT syndrome

Cardiovascular Research ◽

10.1016/j.cardiores.2005.01.017 ◽

2005 ◽

Vol 67 (3) ◽

pp. 459-466 ◽

Cited By ~ 12

Author(s):

J SMITS ◽

M VELDKAMP ◽

C BEZZINA ◽

Z BHUIYAN ◽

H WEDEKIND ◽

...

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Cardiac Sodium Channel Nav1.5 and Drug-Induced Long QT Syndrome

Cardiac Electrophysiology Clinics ◽

10.1016/j.ccep.2014.08.006 ◽

2014 ◽

Vol 6 (4) ◽

pp. 777-783

Author(s):

Hugues Abriel

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Long Qt ◽

Drug Induced ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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A Heterozygous Deletion Mutation in the Cardiac Sodium Channel Gene SCN5A with Loss- and Gain-of-Function Characteristics Manifests as Isolated Conduction Disease, without Signs of Brugada or Long QT Syndrome

PLoS ONE ◽

10.1371/journal.pone.0067963 ◽

2013 ◽

Vol 8 (6) ◽

pp. e67963 ◽

Cited By ~ 13

Author(s):

Sven Zumhagen ◽

Marieke W. Veldkamp ◽

Birgit Stallmeyer ◽

Antonius Baartscheer ◽

Lars Eckardt ◽

...

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Deletion Mutation ◽

Heterozygous Deletion ◽

Long Qt ◽

Gain Of Function ◽

Channel Gene ◽

Sodium Channel Gene ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Malignant Perinatal Variant of Long-QT Syndrome Caused by a Profoundly Dysfunctional Cardiac Sodium Channel

Circulation Arrhythmia and Electrophysiology ◽

10.1161/circep.108.788349 ◽

2008 ◽

Vol 1 (5) ◽

pp. 370-378 ◽

Cited By ~ 31

Author(s):

Dao W. Wang ◽

Lia Crotti ◽

Wataru Shimizu ◽

Matteo Pedrazzini ◽

Francesco Cantu ◽

...

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Long QT Syndrome Associated With a Mutation in the β3 Subunit of the Cardiac Sodium Channel (SCN3B) Gene in Two Siblings

Heart Lung and Circulation ◽

10.1016/j.hlc.2016.06.666 ◽

2016 ◽

Vol 25 ◽

pp. S284-S285

Author(s):

K. Lau ◽

P. Martin ◽

K. Chia ◽

J. McGaughran ◽

J. Atherton

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Enhanced Classification of Brugada Syndrome–Associated and Long-QT Syndrome–Associated Genetic Variants in the SCN5A -Encoded Na v 1.5 Cardiac Sodium Channel

Circulation Cardiovascular Genetics ◽

10.1161/circgenetics.114.000831 ◽

2015 ◽

Vol 8 (4) ◽

pp. 582-595 ◽

Cited By ~ 60

Author(s):

Jamie D. Kapplinger ◽

John R. Giudicessi ◽

Dan Ye ◽

David J. Tester ◽

Thomas E. Callis ◽

...

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Brugada Syndrome ◽

Genetic Variants ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Letter by O’Rourke Regarding Articles, “Prevalence of Long-QT Syndrome Gene Variants in Sudden Infant Death Syndrome,” “Cardiac Sodium Channel Dysfunction in Sudden Infant Death Syndrome,” and “Contribution of Long-QT Syndrome Genes to Sudden Infant Death Syndrome: Is It Time to Consider Newborn Electrocardiographic Screening?”

Circulation ◽

10.1161/circulationaha.107.697540 ◽

2007 ◽

Vol 116 (4) ◽

Cited By ~ 1

Author(s):

Michael F. O’Rourke

Keyword(s):

Sodium Channel ◽

Sudden Infant Death Syndrome ◽

Long Qt Syndrome ◽

Infant Death ◽

Sudden Infant Death ◽

Sudden Infant ◽

Gene Variants ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A

The American Journal of Cardiology ◽

10.1016/s0002-9149(00)01538-1 ◽

2001 ◽

Vol 87 (7) ◽

pp. 909-911 ◽

Cited By ~ 15

Author(s):

Kirsi Piippo ◽

Sam Holmström ◽

Heikki Swan ◽

Matti Viitasalo ◽

Marja Raatikka ◽

...

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Antimalarial Drug ◽

Long Qt ◽

Channel Gene ◽

Sodium Channel Gene ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia

Human Molecular Genetics ◽

10.1093/hmg/4.9.1603 ◽

1995 ◽

Vol 4 (9) ◽

pp. 1603-1607 ◽

Cited By ~ 226

Author(s):

Qing Wang ◽

Jiaxiang Shen ◽

Zhizhong Li ◽

Katherine Timothy ◽

G.Michael Vincent ◽

...

Keyword(s):

Sodium Channel ◽

Cardiac Arrhythmia ◽

Long Qt Syndrome ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: Implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing

Heart Rhythm ◽

10.1016/j.hrthm.2004.07.013 ◽

2004 ◽

Vol 1 (5) ◽

pp. 600-607 ◽

Cited By ~ 229

Author(s):

Michael J. Ackerman ◽

Igor Splawski ◽

Jonathan C. Makielski ◽

David J. Tester ◽

Melissa L. Will ◽

...

Keyword(s):

Genetic Testing ◽

Sodium Channel ◽

Long Qt Syndrome ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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A revised view of cardiac sodium channel “blockade” in the long-QT syndrome

Journal of Clinical Investigation ◽

10.1172/jci9212 ◽

2000 ◽

Vol 105 (8) ◽

pp. 1133-1140 ◽

Cited By ~ 51

Author(s):

Nicholas G. Kambouris ◽

H. Bradley Nuss ◽

David C. Johns ◽

Eduardo Marbán ◽

Gordon F. Tomaselli ◽

...

Keyword(s):

Sodium Channel ◽

Long Qt Syndrome ◽

Channel Blockade ◽

Long Qt ◽

Cardiac Sodium Channel ◽

Qt Syndrome

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