Metabolic engineering of Chinese hamster ovary cells towards reduced biosynthesis and accumulation of novel growth inhibitors in fed-batch cultures

2019 ◽  
Vol 54 ◽  
pp. 54-68 ◽  
Author(s):  
Bhanu Chandra Mulukutla ◽  
Jeffrey Mitchell ◽  
Pauline Geoffroy ◽  
Cameron Harrington ◽  
Manisha Krishnan ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Growth Inhibitors ◽  
Fed Batch ◽  
Ovary Cells ◽  
Batch Cultures

Identification and control of novel growth inhibitors in fed-batch cultures of Chinese hamster ovary cells

2017 ◽  
Vol 114 (8) ◽  
pp. 1779-1790 ◽  
Author(s):  
Bhanu Chandra Mulukutla ◽  
Jaitashree Kale ◽  
Taylor Kalomeris ◽  
Michaela Jacobs ◽  
Gregory W. Hiller
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Growth Inhibitors ◽  
Fed Batch ◽  
Ovary Cells ◽  
Batch Cultures ◽  
And Control

scholarly journals Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

iScience ◽  
2019 ◽  
Vol 12 ◽  
pp. 102-120 ◽  
Author(s):  
Madhuresh Sumit ◽  
Sepideh Dolatshahi ◽  
An-Hsiang Adam Chu ◽  
Kaffa Cote ◽  
John J. Scarcelli ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Time Course ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Fed Batch ◽  
Ovary Cells ◽  
Batch Cultures

Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells

1998 ◽  
Vol 16 (5) ◽  
pp. 468-472 ◽  
Author(s):  
Martin Fussenegger ◽  
Stefan Schlatter ◽  
Daniel Dätwyler ◽  
Xenia Mazur ◽  
James E. Bailey
Keyword(s):  
Metabolic Engineering ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells
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