Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells

1998 ◽  
Vol 16 (5) ◽  
pp. 468-472 ◽  
Author(s):  
Martin Fussenegger ◽  
Stefan Schlatter ◽  
Daniel Dätwyler ◽  
Xenia Mazur ◽  
James E. Bailey
Keyword(s):  
Metabolic Engineering ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells

Metabolic engineering of Chinese hamster ovary cells towards reduced biosynthesis and accumulation of novel growth inhibitors in fed-batch cultures

2019 ◽  
Vol 54 ◽  
pp. 54-68 ◽  
Author(s):  
Bhanu Chandra Mulukutla ◽  
Jeffrey Mitchell ◽  
Pauline Geoffroy ◽  
Cameron Harrington ◽  
Manisha Krishnan ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Growth Inhibitors ◽  
Fed Batch ◽  
Ovary Cells ◽  
Batch Cultures

scholarly journals Metabolic engineering of Chinese hamster ovary cells: Towards a bioengineered heparin

2012 ◽  
Vol 14 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Jong Youn Baik ◽  
Leyla Gasimli ◽  
Bo Yang ◽  
Payel Datta ◽  
Fuming Zhang ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Bioengineered Heparin

Metabolic engineering challenges of extending N-glycan pathways in Chinese hamster ovary cells

2020 ◽  
Vol 61 ◽  
pp. 301-314 ◽  
Author(s):  
Qiong Wang ◽  
Tiexin Wang ◽  
Shuang Yang ◽  
Sha Sha ◽  
Wells W. Wu ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells

Malignancy-related characteristics of wild type and drug-resistant chinese hamster ovary cells

Pathology ◽  
1993 ◽  
Vol 25 (3) ◽  
pp. 268-276 ◽  
Author(s):  
Wanda B. Mackinnon ◽  
Marlen Dyne ◽  
Rebecca Hancock ◽  
Carolyn E. Mountford ◽  
Adrienne J. Grant ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Drug Resistant ◽  
Wild Type ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

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