Elevation of plasma levels of macrophage migration inhibitory factor in patients with acute myocardial infarction

2002 ◽  
Vol 89 (2) ◽  
pp. 248-249 ◽  
Author(s):  
Masafumi Takahashi ◽  
Jun Nishihira ◽  
Takaaki Katsuki ◽  
Eiji Kobayashi ◽  
Uichi Ikeda ◽  
...  
2001 ◽  
Vol 27 (8) ◽  
pp. 1412-1415 ◽  
Author(s):  
Lutz Lehmann ◽  
Uwe Novender ◽  
Stefan Schroeder ◽  
Torsten Pietsch ◽  
Tilman von Spiegel ◽  
...  

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Thorsten Brenner ◽  
Claudia Rosenhagen ◽  
Jochen Steppan ◽  
Christoph Lichtenstern ◽  
Jürgen Weitz ◽  
...  

Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process.Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n=15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n=18) were collected once; samples from postoperative patients (n=28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF.Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0:rsp=0.720,ρ=0.698/t24:rsp=0.771,ρ=0.949).Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.


Cytokine ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 338-340 ◽  
Author(s):  
Julie Delaloye ◽  
Irma J.A. De Bruin ◽  
Katharine E.A. Darling ◽  
Marlies Knaup Reymond ◽  
Fred C.G.J. Sweep ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document