scholarly journals Insulin-Like Growth Factor-Binding Protein 3 Expression Increases during Immortalization of Cervical Keratinocytes by Human Papillomavirus Type 16 E6 and E7 Proteins

2002 ◽  
Vol 161 (2) ◽  
pp. 603-610 ◽  
Author(s):  
Allison J. Berger ◽  
Astrid Baege ◽  
Tracy Guillemette ◽  
James Deeds ◽  
Ron Meyer ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 ◽  
E7 Proteins

Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

2000 ◽  
Vol 20 (17) ◽  
pp. 6483-6495
Author(s):  
Boris Mannhardt ◽  
Stuart A. Weinzimer ◽  
Mechthild Wagner ◽  
Marc Fiedler ◽  
Pinchas Cohen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16 ◽  
Growth Inhibitory

scholarly journals Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

2000 ◽  
Vol 20 (17) ◽  
pp. 6483-6495 ◽  
Author(s):  
Boris Mannhardt ◽  
Stuart A. Weinzimer ◽  
Mechthild Wagner ◽  
Marc Fiedler ◽  
Pinchas Cohen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Growth Factor ◽  
Cell Transformation ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Human Papillomavirus Type 16 ◽  
Growth Inhibitory ◽  
Suppress Cell Proliferation ◽  
Igfbp 3

ABSTRACT The E7 protein encoded by human papillomavirus type 16 is one of the few viral genes that can immortalize primary human cells and thereby override cellular senescence. While it is generally assumed that this property of E7 depends on its interaction with regulators of the cell cycle, we show here that E7 targets insulin-like growth factor binding protein 3 (IGFBP-3), the product of a p53-inducible gene that is overexpressed in senescent cells. IGFBP-3 can suppress cell proliferation and induce apoptosis; we show here that IGFBP-3-mediated apoptosis is inhibited by E7, which binds to IGFBP-3 and triggers its proteolytic cleavage. Two transformation-deficient mutants of E7 failed to inactivate IGFBP-3, suggesting that inactivation of IGFBP-3 may contribute to cell transformation.

Regulation of insulin-like growth factor-binding protein-1 in rat serum

Diabetes ◽  
1994 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M. S. Lewitt ◽  
H. Saunders ◽  
J. L. Phyual ◽  
R. C. Baxter
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Rat Serum ◽  
Factor Binding
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