Rat ovarian insulin-like growth factor binding protein-4: A hormone-dependent granulosa cell-derived antigonadotropin

1997 ◽  
Vol 4 (3) ◽  
pp. 144-151 ◽  
Author(s):  
L PUTOWSKI ◽  
R ROHAN ◽  
D CHOI ◽  
W SCHERZER ◽  
E RICCIARELLI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Granulosa Cell ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Rat Ovarian Insulin-Like Growth Factor Binding Protein-4: A Hormone-Dependent Granulosa Cell-Derived Antigonadotropin

1997 ◽  
Vol 4 (3) ◽  
pp. 144-151 ◽  
Author(s):  
Lechoslaw Putowski ◽  
Richard M. Rohan ◽  
Doo Seok Choi ◽  
Wendy J. Scherzer ◽  
Elisabetta Ricciarelli ◽  
...  
Keyword(s):  
Growth Factor ◽  
Granulosa Cell ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Characterization and Hormonal Regulation of Granulosa Cell-Derived Insulin-Like Growth Factor Binding Protein-4

1996 ◽  
Vol 3 (3) ◽  
pp. 145-151 ◽  
Author(s):  
DooSeok Choi ◽  
Lechoslaw T. Putowski ◽  
Paul J. Fielder ◽  
Ron G. Rosenfeld ◽  
Richard M. Rohan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Granulosa Cell ◽  
Hormonal Regulation ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Insulin-like growth factor binding protein-3 inhibits porcine granulosa cell function in vitro

1995 ◽  
Vol 268 (6) ◽  
pp. E1057-E1064
Author(s):  
S. E. Samaras ◽  
J. M. Hammond
Keyword(s):  
Growth Factor ◽  
Granulosa Cell ◽  
Granulosa Cells ◽  
Cell Function ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Porcine Granulosa Cells ◽  
Igf I ◽  
Igfbp 3

Recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3) effects on basal, insulin-like growth factor I (IGF-I)-, and follicle-stimulating hormone (FSH)-stimulated progesterone (P4) secretion and [3H]aminoisobutyric acid (AIB) uptake by primary porcine granulosa cells (MDGs) and MDGs that have been passaged once (MDGp1) were assessed. Cells were treated concurrently or were preincubated with rhIGFBP-3 followed by treatment. rhIGFBP-3 had no effect on MDG or MDGp1 cell numbers after 24 h. Cotreatment with rhIGFBP-3 inhibited P4 secretion after treatment with FSH, IGF-I, and FSH plus IGF-I. FSH did not stimulate [3H]AIB uptake. However, the IGF-I-stimulated increase in [3H]AIB uptake was completely prevented by concurrent treatment with IGFBP-3. Preincubation of MDGp1 cells with IGFBP-3 dose dependently inhibited FSH- and IGF-I-stimulated P4 secretion. This inhibition was associated with increased cell association of the binding protein and increased IGF-I binding to the cells. These results indicate that IGFBP-3 is inhibitory to a variety of crucial functions in porcine granulosa cells, supporting a role for it in the regulation of granulosa cell function.

Regulation of insulin-like growth factor-binding protein-1 in rat serum

Diabetes ◽  
1994 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M. S. Lewitt ◽  
H. Saunders ◽  
J. L. Phyual ◽  
R. C. Baxter
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Rat Serum ◽  
Factor Binding
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