An analytical model predictive control (MPC) tuning method for multivariable first-order plus fractional dead time systems is presented in this paper. First, the decoupling condition of the closed-loop system is derived, based on which the considered multivariable MPC tuning problem is simplified to a pole placement problem. Given such a simplification, an analytical tuning method guaranteeing the closed-loop stability as well as pre-specified time-domain performance is developed. Finally, simulation examples are provided to show the effectiveness of the proposed method.