scholarly journals Removal of sodium inactivation and block of sodium channels by chloramine-T in crayfish and squid giant axons

1987 ◽  
Vol 52 (2) ◽  
pp. 155-163 ◽  
Author(s):  
J.M. Huang ◽  
J. Tanguy ◽  
J.Z. Yeh
Keyword(s):  
Sodium Channels ◽  
Giant Axons ◽  
Sodium Inactivation ◽  
Chloramine T

scholarly journals Pharmacological Modifications of the Sodium Channels of Frog Nerve

1968 ◽  
Vol 51 (2) ◽  
pp. 199-219 ◽  
Author(s):  
Bertil Hille
Keyword(s):  
Sodium Channels ◽  
Nerve Fibers ◽  
Myelinated Nerve ◽  
Apparent Dissociation Constant ◽  
Specific Change ◽  
Myelinated Nerve Fibers ◽  
Sodium Activation ◽  
Sodium Inactivation ◽  
Na Ions ◽  
Ionic Forms

Voltage clamp measurements on myelinated nerve fibers show that tetrodotoxin, saxitoxin, and DDT specifically affect the sodium channels of the membrane. Tetrodotoxin and saxitoxin render the sodium channels impermeable to Na ions and to Li ions and probably prevent the opening of individual sodium channels when one toxin molecule binds to a channel. The apparent dissociation constant of the inhibitory complex is about 1 nM for the cationic forms of both toxins. The zwitter ionic forms are much less potent. On the other hand, DDT causes a fraction of the sodium channels that open during a depolarization to remain open for a longer time than is normal. The effect cannot be described as a specific change in sodium inactivation or as a specific change in sodium activation, for both processes continue to govern the opening of the sodium channels and neither process is able to close the channels. The effects of DDT are very similar to those of veratrine.

Effects of chloramine-T on activation and inactivation of sodium channels in neuroblastoma cells

1988 ◽  
Vol 19 (6) ◽  
pp. 574-579 ◽  
Author(s):  
E. D. Nosyreva ◽  
I. I. Grishchenko ◽  
Yu. A. Negulyaev
Keyword(s):  
Sodium Channels ◽  
Neuroblastoma Cells ◽  
Chloramine T

Pyrethriod modifications of the activation and inactivation kinetics of the sodium channels in squid giant axons

1990 ◽  
Vol 512 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Jan R. de Weille ◽  
Leslee D. Brown ◽  
Toshio Narahashi
Keyword(s):  
Sodium Channels ◽  
Inactivation Kinetics ◽  
Giant Axons ◽  
Kinetics Of

scholarly journals Binding of tetrodotoxin to squid nerve fibers. Two kinds of receptors?

1976 ◽  
Vol 68 (1) ◽  
pp. 95-103 ◽  
Author(s):  
C Sevcik
Keyword(s):  
Dissociation Constant ◽  
Sodium Channels ◽  
Nerve Fibers ◽  
Affinity Constant ◽  
Sodium Currents ◽  
Apparent Dissociation Constant ◽  
Giant Axons ◽  
Potential Control ◽  
Straight Line ◽  
Two Populations

The effect of tetrodotoxin on the sodium currents of the squid (Doryteuthis plei and Sepioteuthis sepiodea) giant axons was studied under potential control conditions. The axons were immersed in artificial seawater at 21 degrees C and pH 7.5. When the effect of the toxin is studied in concentrations ranging from 0.1 to 50 nM the Eadie-Haldane plot is not a straight line and indicates that there are two populations of sodium channels open during activity. 19.0 +/- 4.7% of the channels are accociated to receptors with an apparent dissociation constant of 0.11 +/- 0.05 nM and 84.0 +/- 4.1% of the channels are related to receptors having an affinity constant of 4.90 +/- 0.49 nM (nine nerves).

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