Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds — an immunocytochemical study using confocal laser scan microscope

1996 ◽  
Vol 741 (1-2) ◽  
pp. 197-204 ◽  
Author(s):  
Isao Hozumi ◽  
Takashi Inuzuka ◽  
Hideaki Ishiguro ◽  
Masao Hiraiwa ◽  
Yoko Uchida ◽  
...  
Keyword(s):  
Rat Brain ◽  
Inhibitory Factor ◽  
Confocal Laser ◽  
Immunocytochemical Study ◽  
Stab Wounds ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Normal Rat ◽  
Confocal Laser Scan Microscope

Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain

2006 ◽  
Vol 395 (3) ◽  
pp. 220-223 ◽  
Author(s):  
Isao Hozumi ◽  
Yoko Uchida ◽  
Kazuhiko Watabe ◽  
Tsuyoshi Sakamoto ◽  
Takashi Inuzuka
Keyword(s):  
Rat Brain ◽  
Brain Damage ◽  
Inhibitory Factor ◽  
Stab Wounds ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory

Changes of growth inhibitory factor after stab wounds in rat brain

1995 ◽  
Vol 688 (1-2) ◽  
pp. 143-148 ◽  
Author(s):  
Isao Hozumi ◽  
Takashi Inuzuka ◽  
Masao Hiraiwa ◽  
Yoko Uchida ◽  
Toshiharu Anezaki ◽  
...  
Keyword(s):  
Rat Brain ◽  
Inhibitory Factor ◽  
Stab Wounds ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory

Expression of Growth Inhibitory Factor mRNA After Focal Ischemia in Rat Brain

1997 ◽  
pp. 745-752 ◽  
Author(s):  
Takamichi Yuguchi ◽  
Eiji Kohmura ◽  
Takayuki Sakaki ◽  
Masahiro Nonaka ◽  
Kazuo Yamada ◽  
...  
Keyword(s):  
Rat Brain ◽  
Focal Ischemia ◽  
Inhibitory Factor ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory

Subcellular localization of growth inhibitory factor in rat brain: light and electron microscopic immunohistochemical studies

1996 ◽  
Vol 735 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Mitsunori Yamada ◽  
Shintaro Hayashi ◽  
Isao Hozumi ◽  
Takashi Inuzuka ◽  
Shoji Tsuji ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Rat Brain ◽  
Inhibitory Factor ◽  
Electron Microscopic ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Immunohistochemical Studies

scholarly journals Could a Growth Inhibitory Factor, Present Only during Pregnancy, be Made Available to Treat Cancer in Adults? A Commentary

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mizejewski GJ
Keyword(s):  
Fetal Growth ◽  
Therapeutic Agent ◽  
Germ Cell Tumors ◽  
Inhibitory Factor ◽  
Additional Function ◽  
Major Function ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Age Dependent ◽  
Growth Promoting

Human alpha-fetoprotein (AFP) is well-known as the “gold standard” biomarker for liver and germ cell tumors. It has also been utilized as a pregnancy screening analyte for neural tube defects as well as Down syndrome, when combined with other gestational-age dependent biomarkers. However, a lesser known and recognized property of AFP is its role in the maintenance and monitoring of fetal growth during ontogenetic development in man. Although a major function of AFP during pregnancy involves the serum transport of estrogens, fatty acids, retinoid, and other compounds, the positive and negative regulation of fetal growth is a vital additional function of AFP. Human AFP largely functions as a growth promoting agent; however, the fetal protein is able to temporarily convert to a growth inhibitory factor in stress and shock environments in the fetal milieu. The development of a transient form of AFP or its derived peptides could be harnessed for use as an adjunct therapeutic agent to treat cancer in adults.

Normal mouse lung tissue produces a growth-inhibitory factor(s) preferential for mouse monocytic leukemia cells

1989 ◽  
Vol 30 (3) ◽  
pp. 139-144 ◽  
Author(s):  
Togo Ikuta ◽  
Yoshio Honma ◽  
Junko Okabe-Kado ◽  
Takashi Kasukabe ◽  
Motoo Hozumi
Keyword(s):  
Lung Tissue ◽  
Normal Mouse ◽  
Inhibitory Factor ◽  
Leukemia Cells ◽  
Mouse Lung ◽  
Monocytic Leukemia ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Mouse Lung Tissue
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