Neonatal transection of the infraorbital nerve increases the expression of proteins related to neuronal death in the principal sensory nucleus of the trigeminal nerve

1997 ◽  
Vol 769 (2) ◽  
pp. 233-244 ◽  
Author(s):  
Michael W Miller ◽  
Peter E Kuhn
1982 ◽  
Vol 25 (3) ◽  
pp. 357-363
Author(s):  
James P. Bowman

The extent to which the known trigeminothalamic projections are related to afferents from specific peripheral branches of the trigeminal nerve is not clearly revealed by degeneration studies involving lesions of the various trigeminal nuclei. This study examines the ascending projections related to the lingual branch of the trigeminal nerve using the evoked-potential technique in pentobarbital anesthetized rhesus monkeys. The distribution of potentials within the medulla, pons, and midbrain was determined by recording with macroelectrodes following single-pulse stimulation of the lingual nerve. Results show that two pathways from the main sensory nucleus convey lingual nerve information to the thalamic ventral posteromedial nucleus: an ipsilateral projection which in position corresponds to the dorsal trigeminal tract, and a larger contralateral projection which in position corresponds to the crossed ventral trigeminal tract, or trigeminal lemniscus. Additionally, the spinal trigeminal nucleus contributes fibers of lingual nerve origin to the contralateral medial lemniscus. The role of low-threshold mechanoreceptive information in lingual sensorimotor activity is discussed in relation to current concepts of somatosensory system function.


2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Sasitorn Siritho ◽  
Wadchara Pumpradit ◽  
Wiboon Suriyajakryuththana ◽  
Krit Pongpirul

A 43-year-old female presented with severe sharp stabbing right-sided periorbital and retroorbital area headache, dull-aching unilateral jaw pain, eyelid swelling, ptosis, and tearing of the right eye but no rash. The pain episodes lasted five minutes to one hour and occurred 10–15 times per day with unremitting milder pain between the attacks. She later developed an erythematous maculopapular rash over the right forehead and therefore was treated with antivirals. MRI performed one month after the onset revealed small hypersignal-T2 in the right dorsolateral mid-pons and from the right dorsolateral aspect of the pontomedullary region to the right dorsolateral aspect of the upper cervical cord, along the course of the principal sensory nucleus and spinal nucleus of the right trigeminal nerve. No definite contrast enhancement of the right brain stem/upper cervical cord was seen. Orbital imaging showed no abnormality of bilateral optic nerves/chiasm, extraocular muscles, and globes. Slight enhancement of the right V1, V2, and the cisterna right trigeminal nerve was detected. Our findings support the hypothesis of direct involvement by virus theory, reflecting rostral viral transmission along the gasserian ganglion to the trigeminal nuclei at brainstem and caudal spreading along the descending tract of CN V.


2017 ◽  
Vol 10 (3) ◽  
pp. 208-211 ◽  
Author(s):  
Amir H. Dorafshar ◽  
A.Lee Dellon ◽  
EricLee Wan ◽  
Sashank Reddy ◽  
Victor W. Wong

Posttraumatic facial pain is due to an injured nerve, most often a branch of the trigeminal nerve. While surgical approaches to injuries of the supraorbital, supratrochlear, infraorbital, and inferior alveolar nerves have been reported, an injury to the anterior superior alveolar nerve (ASAN) has not been reported. An algorithm is proposed for the diagnosis of injury to the ASAN versus the infraorbital nerve itself. A case is reported in which pain relief was achieved by dividing the ASAN within the maxillary sinus, leaving the proximal end exposed within the sinus at the level of the orbital floor.


Cephalalgia ◽  
2008 ◽  
Vol 28 (9) ◽  
pp. 980-985 ◽  
Author(s):  
I Garza

The trigeminal trophic syndrome is an unusual consequence of trigeminal nerve injury that results in facial anaesthesia, dysaesthesia and skin ulceration. Limited knowledge is available. The aim of this study was to increase the knowledge of this syndrome by performing a retrospective medical record review and case series report. Fourteen cases were identified. The female : male ratio was 6:1. Mean age of onset was 45 years (range 6-82). The cause was iatrogenic in most. Latent period to onset ranged from days to almost one decade. The majority ( n = 12) had bothersome dysaesthesias. Most ( n = 9) self-manipulated the face; a third ( n = 5) did not. Most ulcers affected the second trigeminal division, mainly in the infraorbital nerve distribution. Neuropathic and/or neuralgic facial pain occurred in 50% ( n = 7). Pain intensity was severe in most (n = 6). Gabapentin gave relief in two. To conclude, trigeminal trophic syndrome follows injury to the trigeminal nerve or its nuclei. For unclear reasons, most ulcerations follow infraorbital nerve distribution. Self-manipulation may contribute to ulcer development rather than being required. Gabapentin may help pain.


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