Modulation of quinolinic acid-induced depletion of striatal NADPH diaphorase and enkephalinergic neurons by inhibition of nitric oxide synthase

1999 ◽  
Vol 817 (1-2) ◽  
pp. 151-162 ◽  
Author(s):  
Bettina E. Kalisch ◽  
Khem Jhamandas ◽  
Richard J. Beninger ◽  
Roland J. Boegman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Quinolinic Acid ◽  
Nadph Diaphorase ◽  
Oxide Synthase

Morphological analyses of NADPH-diaphorase/nitric oxide synthase positive structures in human visual cortex

1994 ◽  
Vol 23 (12) ◽  
pp. 770-782 ◽  
Author(s):  
Hans -Joachim L�th ◽  
Annelies Hedlich ◽  
Heidegard Hilbig ◽  
Ernst Winkelmann ◽  
Bernd Mayer
Keyword(s):  
Nitric Oxide ◽  
Visual Cortex ◽  
Nitric Oxide Synthase ◽  
Nadph Diaphorase ◽  
Human Visual Cortex ◽  
Oxide Synthase

A radiometric analysis of nitric oxide synthase activity in Hymenolepis diminuta

Parasitology ◽  
2000 ◽  
Vol 120 (1) ◽  
pp. 91-95 ◽  
Author(s):  
N. B. TERENINA ◽  
M. V. ONUFRIEV ◽  
N. V. GULYAEVA ◽  
A. M. LINDHOLM ◽  
M. K. S. GUSTAFSSON
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Nitric Oxide Synthase ◽  
Nadph Diaphorase ◽  
Hymenolepis Diminuta ◽  
Complete Reduction ◽  
Radiometric Analysis ◽  
Nos Inhibitors ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

The free radical nitric oxide (NO) is a neuronal messenger which is synthesized from L-arginine and O2 by nitric oxide synthase (NOS). In the synthesis NO and L-citrulline are produced in a stoichiometric 1[ratio ]1 relation. The activity of NOS was analysed in homogenates of the rat tapeworm Hymenolepis diminuta by measuring the formation of L-[3H]citrulline after incubation with L-[3H]arginine. The nature of NOS in H. diminuta was determined by studying the effect of 3 types of NOS inhibitors: (1) L-NAME, (2) EGTA, (3) 7-nitro-indazole. All inhibitors caused a significant but not complete reduction in the formation of L-[3H]citrulline. The results are discussed against the background of nerve cells and fibres positive for NADPH-diaphorase staining in H. diminuta.

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