Impact of oral contraceptive use on APC-resistance: a prospective, randomized clinical trial with three low-dose preparations

Contraception ◽  
2001 ◽  
Vol 64 (4) ◽  
pp. 217-222 ◽  
Author(s):  
J. Endrikat ◽  
M. Noah ◽  
C. Gerlinger ◽  
R. Bannemerschult ◽  
W. Junge ◽  
...  
2017 ◽  
Vol 14 (2) ◽  
pp. 40-43
Author(s):  
Abida Sultana ◽  
Kashefa Khatun ◽  
Al Mamun Mahbub Alam

AbstractBackground: Duration of oral contraceptive use is an important issue for the development of dyslipidemia among women.Objective: The purpose of the present study was to see the duration of use of OCP and the development of dyslipidemia among the women.Methodology: This case control study was carried out in the Department of Obstetrics & Gynaecology and Family Planning Department in collaboration with the Biochemistry Department at Sir Salimullah Medical College & Mitford Hospital, Dhaka from June 2009 to May 2010 for a period of one (1) year. Women using low-dose OC pill for more than one year were considered as cases group while women not using low-dose oral contraceptive pill were taken as control group of the study. Lipid profiles were performed in the laboratory in the fasting state from blood.Result: A total of 80 subjects were recruited for this study of which 40 women in case group and the rest 40 women were in control group. Duration of contraceptive use and serum lipids profiles were recorded. Level of serum total cholesterol, serum triglyceride, and serum LDL were significantly higher among the contraceptive users of > 5 years duration than those among 5 or < 5 years duration (p < 0.001). However, serum HDL level was low among both users and non-users (p=0.556). The risk of developing dyslipidaemia in women using low-dose oral contraceptive was more than 3-fold higher than that in non-users.Conclusion: In conclusion the greater the duration of oral contraceptive use the higher is the chance of dyslipidaemia.Journal of Science Foundation 2016;14(2):40-43


2022 ◽  
Author(s):  
Joo-Hee Chun ◽  
Amanda Cunha Regal Castro ◽  
Sunmee Oh ◽  
Kyung-Ho Kim ◽  
Sung-Hwan Choi ◽  
...  

Abstract Background: This prospective randomized clinical trial aimed to evaluate the short-term effects of rapid palatal expansion (RPE) and miniscrew-assisted RPE (MARPE) on skeletal, dentoalveolar, and periodontal structures in adolescent and young adult patients. Methods: Thirty-six patients (12 men and 24 women) requiring maxillary expansion were randomly allocated to RPE (n=17) or MARPE (n=19) groups. Upon identical (35 turns) amount of expansion, low-dose cone-beam computed tomography images were taken before treatment (T0), immediately after expansion (T1), and after a 3-month consolidation period (T2). Skeletal, dentoalveolar, and periodontal measurements were performed at each time point. Results: A greater increase in nasal width in the molar region (M-NW) and greater palatine foramen (GPF) was observed immediately after expansion (T1-T0) and consolidation periods (T2-T0) in MARPE group (P<0.05). MARPE and RPE groups showed similar dentoalveolar changes except for the maxillary width (PM-MW, M-MW) (P<0.05). Through the expansion and consolidation periods (T2-T0), lesser buccal displacement of the anchor teeth was observed in the MARPE group (PM-BBPT, PM-PBPT, M-BBPT [mesial and distal roots], and M-PBPT) (P<0.05).Conclusions: Both RPE and MARPE groups exhibited significant triangular basal bone expansion and skeletal relapse during consolidation. Under identical amounts of expansion, the MARPE group showed lower decrease in the skeletal, dentoalveolar and periodontal variables after consolidation. The reinforcement of RPE with miniscrews contributes to the maintenance of the basal bone during consolidation period. This evidence can help clinicians decide the appliance design for maxillary expansion, while preventing periodontal side effects, such as buccal bone dehiscence Trial registration: WHO Institutional Clinical Trials Registry Platform (IRB No. KCT0006871 / Registration Date 27/12/2021)


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