Impaired Temporal Context Memory on Anterograde But Not Retrograde Tests in the Absence of Frontal Pathology

BackgroundThe context memory deficit hypothesis of schizophrenia postulates that the long-term deficit associated with this disorder is related to a memory impairment for contextual information.MethodTo test this hypothesis, memory for temporal context was assessed in 33 patients with schizophrenia and 33 normal subjects, using a recency discrimination task.ResultsWhereas patients were able to recall and recognise target items, they were unable to recognise from among the target items those which had been most recently learned.ConclusionsSchizophrenia is associated with a temporal context memory deficit.

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Neural basis of temporal context memory: A functional MRI study

NeuroImage ◽

10.1016/s1053-8119(01)92088-9 ◽

2001 ◽

Vol 13 (6) ◽

pp. 746

Author(s):

Maki Suzuki ◽

Toshikatsu Fujii ◽

Takashi Tsukiura ◽

Jiro Okuda ◽

Atsushi Umetsu ◽

...

Keyword(s):

Functional Mri ◽

Temporal Context ◽

Neural Basis ◽

Mri Study ◽

Context Memory

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Group differences in anterior hippocampal volume and in the retrieval of spatial and temporal context memory in healthy young versus older adults

Neuropsychologia ◽

10.1016/j.neuropsychologia.2010.10.010 ◽

2010 ◽

Vol 48 (14) ◽

pp. 4020-4030 ◽

Cited By ~ 51

Author(s):

M. Natasha Rajah ◽

Michelle Kromas ◽

Jung Eun Han ◽

Jens C. Pruessner

Keyword(s):

Older Adults ◽

Hippocampal Volume ◽

Group Differences ◽

Temporal Context ◽

Context Memory

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Orbito-frontal Cortex is Necessary for Temporal Context Memory

Journal of Cognitive Neuroscience ◽

10.1162/jocn.2009.21316 ◽

2010 ◽

Vol 22 (8) ◽

pp. 1819-1831 ◽

Cited By ~ 48

Author(s):

Audrey Duarte ◽

Richard N. Henson ◽

Robert T. Knight ◽

Tina Emery ◽

Kim S. Graham

Keyword(s):

Frontal Cortex ◽

Critical Role ◽

Spatial Context ◽

Temporal Context ◽

Imaging Results ◽

Temporal Aspects ◽

Neuropsychological Investigation ◽

Temporal And Spatial ◽

Context Memory ◽

Encoding And Retrieval

Lesion and neuroimaging studies suggest that orbito-frontal cortex (OFC) supports temporal aspects of episodic memory. However, it is unclear whether OFC contributes to the encoding and/or retrieval of temporal context and whether it is selective for temporal relative to nontemporal (spatial) context memory. We addressed this issue with two complimentary studies: functional magnetic resonance imaging to measure OFC activity associated with successful temporal and spatial context memory during encoding and retrieval in healthy young participants, and a neuropsychological investigation to measure changes in spatial and temporal context memory in OFC lesion patients. Imaging results revealed that OFC contributed to encoding and retrieval of associations between objects and their temporal but not their spatial contexts. Consistent with this, OFC patients exhibited impairments in temporal but not spatial source memory accuracy. These results suggest that OFC plays a critical role in the formation and subsequent retrieval of temporal context.

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