Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

2003 ◽  
Vol 466 (1-2) ◽  
pp. 99-111 ◽  
Author(s):  
Wolfgang Löscher ◽  
Heidrun Potschka ◽  
Piotr Wlaź ◽  
Wojciech Danysz ◽  
Christopher G Parsons
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug ◽  
Nicotinic Receptors ◽  
Development Studies ◽  
Neuronal Nicotinic Receptors ◽  
Seizure Models

scholarly journals Qualification of translational safety biomarkers

2021 ◽  
pp. 153537022110021
Author(s):  
John-Michael Sauer ◽  
Amy C Porter
Keyword(s):  
Skeletal Muscle ◽  
Drug Development ◽  
Vascular Injury ◽  
Validation Studies ◽  
Safety Assessment ◽  
Regulatory Agencies ◽  
Development Studies ◽  
Clinical Validation ◽  
Development Tools ◽  
Important Drug

Safety biomarkers are important drug development tools, both preclinically and clinically. It is a straightforward process to correlate the performance of nonclinical safety biomarkers with histopathology, and ideally, the biomarker is useful in all species commonly used in safety assessment. In clinical validation studies, where histopathology is not feasible, safety biomarkers are compared to the response of standard biomarkers and/or to clinical adjudication. Worldwide, regulatory agencies have put in place processes to qualify biomarkers to provide confidence in the manner of use and interpretation of biomarker data in drug development studies. This paper describes currently qualified safety biomarkers which can be utilized to monitor for nephrotoxicity and cardiotoxicity and ongoing projects to qualify safety biomarkers for liver, skeletal muscle, and vascular injury. In many cases, the development and use of these critical drug development tools is dependent upon partnerships and the precompetitive sharing of data to support qualification efforts.

Recombinant extracellular domains of human neuronal nicotinic receptors: Preliminary studies on mutant forms for the improvement of solubility

2007 ◽  
Vol 39 (4-5) ◽  
pp. 259-263
Author(s):  
M. Zouridakis ◽  
P. Zisimopoulou ◽  
E. Eliopoulos ◽  
L. Jacobson ◽  
K. Poulas ◽  
...  
Keyword(s):  
Nicotinic Receptors ◽  
Neuronal Nicotinic Receptors ◽  
Extracellular Domains ◽  
Mutant Forms

scholarly journals Differential Expression of α-Bungarotoxin-Sensitive Neuronal Nicotinic Receptors in Adrenergic Chromaffin Cells: A Role for Transcription Factor Egr-1

1997 ◽  
Vol 17 (17) ◽  
pp. 6554-6564 ◽  
Author(s):  
Manuel Criado ◽  
Eduardo Domı́nguez del Toro ◽  
Carmen Carrasco-Serrano ◽  
Frazer I. Smillie ◽  
José M. Juı́z ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Differential Expression ◽  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Neuronal Nicotinic Receptors

Antiepileptic Drug Development in Children

Drugs ◽  
2008 ◽  
Vol 68 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Catherine Chiron ◽  
Olivier Dulac ◽  
Gerard Pons
Keyword(s):  
Drug Development ◽  
Antiepileptic Drug
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