471 The Learning Curve of In Vivo Confocal Laser Endomicroscopy for Prediction of Barrett's Esophagus

2008 ◽  
Vol 134 (4) ◽  
pp. A-62-A-63 ◽  
Author(s):  
Kerry B. Dunbar ◽  
Elizabeth A. Montgomery ◽  
Marcia I. Canto
Keyword(s):  
Learning Curve ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser

In Vivo Histology of Barrett's Esophagus and Associated Neoplasias By Confocal Laser Endomicroscopy

2005 ◽  
Vol 61 (5) ◽  
pp. AB101 ◽  
Author(s):  
Ralf Kiesslich ◽  
Liebwin Gossner ◽  
Alexandra Dahlmann ◽  
Michael Vieth ◽  
Manfred Stolte ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser

In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy

2006 ◽  
Vol 4 (8) ◽  
pp. 979-987 ◽  
Author(s):  
Ralf Kiesslich ◽  
Liebwin Gossner ◽  
Martin Goetz ◽  
Alexandra Dahlmann ◽  
Michael Vieth ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser

Confocal Laser Endomicroscopy for in-vivo Diagnosis of Barrett's Esophagus and Associated Neoplasia: An Ongoing Prospective Study

2008 ◽  
Vol 67 (5) ◽  
pp. AB97 ◽  
Author(s):  
Cristina Trovato ◽  
Angelica Sonzogni ◽  
Giancarla Fiori ◽  
Davide Ravizza ◽  
Darina Tamayo ◽  
...  
Keyword(s):  
Prospective Study ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
In Vivo Diagnosis

scholarly journals In Vivo Molecular Imaging of Barrett's Esophagus With Confocal Laser Endomicroscopy

2013 ◽  
Vol 145 (1) ◽  
pp. 56-58 ◽  
Author(s):  
Matthew B. Sturm ◽  
Cyrus Piraka ◽  
B. Joseph Elmunzer ◽  
Richard S. Kwon ◽  
Bishnu P. Joshi ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser

scholarly journals Probe-based confocal laser endomicroscopy and Barrett's esophagus – just a scientific toy or significant improvement in diagnosis?

2021 ◽  
Author(s):  
Luka Vranić ◽  
Tin Nadarević ◽  
Davor Štimac
Keyword(s):  
Diagnostic Accuracy ◽  
Real Time ◽  
Barrett’S Esophagus ◽  
Predictive Value ◽  
Barrett's Esophagus ◽  
High Reliability ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Imaging Method ◽  
Increased Risk

Background: Barrett’s esophagus (BE) requires surveillance to identify potential neoplasia at early stage. Standard surveillance regimen includes random four-quadrant biopsies by Seattle protocol. Main limitations of random biopsies are high risk of sampling error, difficulties in histology interpretation, common inadequate classification of pathohistological changes, increased risk of bleeding and time necessary to acquire the final diagnosis. Probe-based confocal laser endomicroscopy (pCLE) has emerged as a potential tool with an aim to overcome these obvious limitations. Summary: pCLE represents real-time microscopic imaging method that offers evaluation of epithelial and subepithelial structures with 1000-fold magnification. In theory, pCLE has potential to eliminate the need for biopsy in BE patient. The main advantages would be real-time diagnosis and decision making, greater diagnostic accuracy and to evaluate larger area compared to random biopsies. Clinical pCLE studies in esophagus show high diagnostic accuracy and its high negative predictive value offers high reliability and confidence to exclude dysplastic and neoplastic lesions. However, it still cannot replace histopathology due to lower positive predictive value and sensitivity. Key messages: Despite promising results, its role in routine use in patients with Barrett’s esophagus remains questionable primarily due to lack of well-organized double-blind randomized trials.

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