A multicenter, partially blinded, randomised study of the efficacy of photodynamic therapy (PDT) using porfimer sodium (POR) for the ablation of high-grade dysplasia (HGD) in Barrett's esophagus (BE): Results of 6-month follow-up

2001 ◽  
Vol 120 (5) ◽  
pp. A79 ◽  
Author(s):  
Bergein F. Overholt ◽  
Rodger C. Haggitt ◽  
Mary P. Bronner ◽  
Shari L. Taylor ◽  
Yong Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Randomised Study ◽  
Porfimer Sodium

scholarly journals Photodynamic Therapy in Barrett’s Esophagus: Results of Treatment of 17 Patients

2006 ◽  
Vol 20 (4) ◽  
pp. 261-264 ◽  
Author(s):  
Alan A Weiss ◽  
Holly AR Wiesinger ◽  
David Owen
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Argon Plasma Coagulation ◽  
Argon Plasma ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Early Adenocarcinoma

BACKGROUND: Barrett’s esophagus (BE) with dysplasia may progress to esophageal adenocarcinoma. Photodynamic therapy is a promising treatment for BE.OBJECTIVE: To determine if photodynamic therapy is an acceptable alternative to esophagectomy in BE patients with high-grade dysplasia or early adenocarcinoma.METHODS: Seventeen patients were treated with photodynamic therapy for BE and high-grade dysplasia or early esophageal adenocarcinoma. Patients with residual Barrett’s epithelium were treated with supplemental argon plasma coagulation or potassium titanyl phosphate laser. Patients underwent follow-up endoscopy three, six, nine and 12 months post-treatment, then every six to 12 months. Mean follow-up was 21 months.RESULTS: High-grade dysplasia or early adenocarcinoma was completely eliminated in nine of 15 (60%) patients. High-grade dysplasia was downgraded in one patient, persisted in one patient and progressed in four patients. Two patients with early esophageal adenocarcinoma were nonresponders. Complications included stricture, sunburn, urticaria, small pleural effusions, esophageal spasm and transient atrial fibrillation.CONCLUSIONS: Photodynamic therapy with supplemental ablation is a good, noninvasive therapy for elimination of high-grade dysplasia and early adenocarcinoma in BE. Failure to eliminate dysplastic epithelium occurred in 40% of the patients, thereby necessitating careful follow-up.

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