radiofrequency ablation
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2022 ◽  
Vol 36 (1) ◽  
pp. 2-6
Nobuhisa Yamazaki ◽  
Yuuki Kou ◽  
Yasuto Sakaguchi ◽  
Hirokazu Tanaka ◽  
Makoto Sonobe

2022 ◽  
Vol 11 (2) ◽  
pp. 434
Hiroaki Takaya ◽  
Tadashi Namisaki ◽  
Kazusuke Matsumoto ◽  
Junya Suzuki ◽  
Koji Murata ◽  

Radiofrequency ablation (RFA) is recommended in Japan for patients with hepatocellular carcinomas (HCCs) one to three in number and ≤3 cm in size. The arfa® and VIVA® RFA systems are widely used for patients with HCC and this retrospective observational study aims to compare their performances. The study included 365 patients with HCCs one to three in number and ≤3 cm in size who underwent RFA using the arfa® system (arfa® group) or the VIVA® system (VIVA® group). The total bilirubin (T-Bil) level after RFA was higher in the arfa® group than in the VIVA® group. With a 3-cm electrode needle, the longest diameter (Dmax) and the shortest diameter were analyzed and found to be greater in the arfa® group than in the VIVA® group. Furthermore, Dmax with the 2.5-cm electrode needle was greater in the arfa® group than in the VIVA® group. Statistically significant differences in the ablation area and in the T-Bil value after RFA were observed between the groups; however, these differences are not considered clinical problems because the difference in the ablation area was only slight and the Child–Pugh score was the same between the groups. Thus, hepatologists can use either of the RFA systems based on their preference.

2022 ◽  
Vol 14 (1) ◽  
pp. 203-215
Richard Hendriquez ◽  
Tara Keihanian ◽  
Jatinder Goyal ◽  
Rtika R Abraham ◽  
Rajnish Mishra ◽  

2022 ◽  
Vol 38 (3) ◽  
Xiaoru Qin ◽  
Xiaofei Jiang ◽  
Qiyan Yuan ◽  
Guangli Xu ◽  
Xianzhi He

Objective: To explore the optimal ablation index (AI) parameters for radiofrequency catheter ablation (RA) for treating atrial fibrillation (AF). Method: Patients with AF (186) who underwent bilateral PVAI in the Department of Cardiology, Zhuhai People’s Hospital, Guangdong Province, from March 2018 to October 2019 and received catheter ablation as first-round treatment, were grouped according to the received AI. Control group included patients (95) who received the recommended AI ablation (350–400 for posterior wall, 400–450 for non-posterior wall). Patients in optimal AI group were ablated with optimal AI (300–330 for posterior wall, 350–380 for non-posterior wall). Results: Of 186 patients, 66 patients had paroxysmal atrial fibrillation and a mean CHA2DS2-VASc score of 2.83±1.64. Isolation rates of bilateral PVI in both groups were 91.4% and 93.6%, for patients with paroxysmal atrial fibrillation, and 81.7% and 80% for patients with persistent atrial fibrillation (P > 0.05). Left atrial function index (LAFI) decreased under the condition of sinus rhythm at the 3rd and 6th months (P < 0.05). LAFI improvement was significantly better in the optimal AI group than in the control group (P < 0.05). Rates of pain and cough during the ablation, and postoperative gastrointestinal discomfort and use of PPIs were higher in the control group (P < 0.05). Conclusion: Radiofrequency ablation of AF, guided by optimal AI combined with impedance, can minimize atrial injury, prevent atrial failure, promote the recovery of atrial function, reduces intraoperative cough, pain, and postoperative gastrointestinal discomfort and use of PPIs. doi: How to cite this:Qin X, Jiang X, Yuan Q, Xu G, He X. Optimal ablation index parameters for radiofrequency ablation therapy of atrial fibrillation. Pak J Med Sci. 2022;38(3):---------. doi: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Andrew Tran ◽  
David A. Reiter ◽  
Jan Fritz ◽  
Anna R. Cruz ◽  
Nickolas B. Reimer ◽  

2022 ◽  
Vol 12 ◽  
Yu Hao ◽  
Zhikai Lei ◽  
Nanjing Shi ◽  
Lingying Yu ◽  
Weiqin Ji ◽  

ObjectiveWe identified a novel inactivating mutation in the calcium-sensing receptor (CaSR) gene in a patient with refractory hypocalciuric hypercalcemia and analyzed its function. The effectiveness of radiofrequency ablation of the parathyroid glands to treat hypercalcemia caused by this mutation was explored.MethodsClinical data of patients before and after radiofrequency ablation were retrospectively analyzed. The CaSR mutation (D99N) found in the patient was studied in cell lines. HEK-293 cells were transfected with plasmids containing wild-type (WT) or mutant CaSR genes (D99N and W718X). Expression levels of the respective CaSR proteins were measured, and their functions were assessed by examining the effect of NPS R-568 (a CaSR agonist) on intracellular Ca2+ oscillations and that of exogenous parathyroid hormone (PTH) on intracellular cyclic adenosine monophosphate (cAMP) levels.ResultsThe effectiveness of pharmacological treatment was poor, whereas radiofrequency ablation of the parathyroid glands resulted in controlled blood calcium and PTH levels in the patient. In cell lines, upon NPS R-568 administration, the amplitude of intracellular Ca2+ oscillations in the D99N group was lower than that in the WT group and higher than that in the W718X group. Upon administration of PTH, intracellular cAMP levels in the D99N group were higher than those in the WT group and lower than those in the W718X group.ConclusionThe homozygous mutation D99N reduced CaSR activity and caused more severe hypocalciuric hypercalcemia. For patients with this type of hypercalcemia and poor response to pharmacological treatments, radiofrequency ablation of the parathyroid glands may be a suitable treatment option.

2022 ◽  

Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

2022 ◽  
Vol 6 ◽  
pp. 2
Benson Li ◽  
Serenella Serinelli ◽  
Gustavo de la Rosa ◽  
Timothy Arthur Damron

Needle biopsy of an incidental periacetabular bone lesion in an 18-year-old female showed a low-grade cartilaginous tumor. Based on the imaging and pelvic location, the tumor was considered a Grade I chondrosarcoma. Due to the young age, incidental discovery, and low metastatic potential, radiofrequency ablation (RFA) was recommended in favor over traditional wide en bloc resection. The patient has been radiographically and clinically stable for 2 years. RFA has not been previously reported for low-grade chondrosarcoma. Its use should be done only with careful consideration and diligent follow-up in this setting.

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