T1899 Achalasia Cardia Subtyping Based on Pressure Topography on High Resolution Manometry Can Predict Therapeutic Outcome of Endoscopic Pneumatic Dilatation

2010 ◽  
Vol 138 (5) ◽  
pp. S-602
Author(s):  
Nitesh Pratap ◽  
Rakesh Kalapala ◽  
Mohan Ramchandani ◽  
Rupa Banerjee ◽  
Sandeep Lakhtakia ◽  
...  
2016 ◽  
Vol 150 (4) ◽  
pp. S93-S94
Author(s):  
Michael Bennett ◽  
Amit Patel ◽  
Nitin Sainani ◽  
Dan Wang ◽  
Gregory S. Sayuk ◽  
...  

2020 ◽  
pp. 106-117
Author(s):  
Mohan Ramchandani ◽  
Partha Pal

Achalasia cardia is the best characterised oesophageal motility disorder. It is characterised by progressive ganglion cell degeneration in the oesophageal myenteric plexus, which results in impaired lower oesophageal sphincter (LES) relaxation upon swallowing and aperistalsis in the distal smooth muscle segment of the oesophagus. The usual presenting features are dysphagia to both liquids and solids from onset, regurgitation of undigested food, retrosternal pain, heartburn, and weight loss. Initial investigations include upper gastrointestinal (GI) endoscopy and timed barium oesophagogram, whereas high resolution manometry is diagnostic. Therapy in achalasia cardia is directed towards biochemical or mechanical reduction in LES pressures. If candidates are fit for surgery, pneumatic dilatation, peroral endoscopic myotomy, and laparoscopic Heller’s myotomy are the mainstays of therapy that act by mechanical disruption of LES. On the other hand, botulinum toxin and pharmacotherapy (nitrates and calcium channel blockers) act by biochemical reduction of LES and are reserved for surgically unfit patients with limited life expectancy because of their short-lived efficacy. Oesophagectomy is reserved for treating refractory longstanding cases, who have previously failed multiple therapies.


Digestion ◽  
2013 ◽  
Vol 87 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Hiroshi Yamashita ◽  
Kiyoshi Ashida ◽  
Takumi Fukuchi ◽  
Yoshiaki Nagatani ◽  
Hideaki Koga ◽  
...  

2019 ◽  
Vol 26 (4) ◽  
pp. e452-e461 ◽  
Author(s):  
Hyuk Lee ◽  
Hyunsoo Chung ◽  
Tae Hee Lee ◽  
Kyoung Sup Hong ◽  
Young Hoon Youn ◽  
...  

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