Antibodies to Vinculin and Cytolethal Distending Toxin B (IBSchek) are Associated with a Post-Infectious Aetiology in Patients with Mixed Bowel Habit IBS but not Small Intestinal Bacterial Overgrowth, Quality of Life or Changes in Gastrointestinal Motility

2017 ◽  
Vol 152 (5) ◽  
pp. S718-S719
Author(s):  
Adam D. Farmer ◽  
Anthony Hobson
Keyword(s):  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Bowel Habit ◽  
Cytolethal Distending Toxin ◽  
Toxin B ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal ◽  
Infectious Aetiology ◽  
Post Infectious

scholarly journals Treating irritable bowel syndrome with probiotics: the evidence

2010 ◽  
Vol 69 (2) ◽  
pp. 187-194 ◽  
Author(s):  
G. C. Parkes ◽  
J. D. Sanderson ◽  
K. Whelan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Bacterial Overgrowth ◽  
Abdominal Distension ◽  
Small Intestinal Bacterial Overgrowth ◽  
Bowel Habit ◽  
Altered Bowel Habit ◽  
Small Intestinal ◽  
Irritable Bowel ◽  
Developed World ◽  
Post Infectious

Irritable bowel syndrome (IBS) is a disorder of chronic abdominal pain, altered bowel habit and abdominal distension. It is the commonest cause of referral to gastroenterologists in the developed world and yet current therapeutic strategies are often unsatisfactory. There is now increasing evidence linking alterations in the gastrointestinal (GI) microbiota and IBS. Changes in faecal and mucosa-associated microbiota, post-infectious IBS, a link with small intestinal bacterial overgrowth and an up-regulation of the GI mucosal immune system all suggest a role for the GI microbiota in the pathogenesis of IBS. Given this evidence, therapeutic alteration of the GI microbiota by probiotic bacteria could be beneficial. The present paper establishes an aetiological framework for the use of probiotics in IBS and comprehensively reviews randomised placebo-controlled trials of probiotics in IBS using multiple electronic databases. It highlights safety concerns over the use of probiotics and attempts to establish guidelines for their use in IBS in both primary and secondary care.

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