Effect of a specific synthetic inhibitor of neutrophil elastase(ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs

1998 ◽  
Vol 114 ◽  
pp. A1396
Author(s):  
M. Imamura ◽  
Y. Mikami ◽  
H. Takahashi
Keyword(s):  
Neutrophil Elastase ◽  
Hemorrhagic Pancreatitis ◽  
Synthetic Inhibitor ◽  
Acute Hemorrhagic Pancreatitis

Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs

1998 ◽  
Vol 5 (4) ◽  
pp. 422-428 ◽  
Author(s):  
Mikio Imamura ◽  
Yukio Mikami ◽  
Hiroki Takahashi ◽  
Hidemi Yamauchi
Keyword(s):  
Neutrophil Elastase ◽  
Hemorrhagic Pancreatitis ◽  
Synthetic Inhibitor ◽  
Acute Hemorrhagic Pancreatitis

THE SELECTIVE PROTEOLYTIC ENZYME INHIBITORY ACTION OF BENZETHONIUM CHLORIDE

1960 ◽  
Vol 38 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Ivan T. Beck ◽  
E. Pinter ◽  
R. D. McKenna ◽  
H. Griff
Keyword(s):  
Subcutaneous Injection ◽  
Proteolytic Enzyme ◽  
Inhibitory Action ◽  
Hemorrhagic Pancreatitis ◽  
Benzethonium Chloride ◽  
Tryptic Activity ◽  
High Concentrations ◽  
Acute Hemorrhagic Pancreatitis ◽  
Very High

Acute hemorrhagic pancreatitis in humans is thought to be perpetuated by the autolytic processes catalyzed by trypsin and lipase. This study is an integral part of our search for trypsin and lipase inhibitors to be used in the treatment of this disease.Benzethonium chloride was found to inhibit tryptic activity in vitro. The proteolytic activity of rabbit's serum was inhibited, and the inhibition was most pronounced 6 to 12 hours after the subcutaneous injection of the compound. Fibrinolysin was also inhibited in vitro but benzethonium chloride had no inhibitory action on chymotrypsin, pepsin, or lipase.Serum proteins in vitro were precipitated only with very high concentrations of the compound. No significant protein changes were observed in sera of rabbits after the subcutaneous injection of the compound.

scholarly journals Acute Hemorrhagic Pancreatitis and Pseudocyst Due to Mumps

1974 ◽  
Vol 180 (1) ◽  
pp. 85-88 ◽  
Author(s):  
JEFFREY D. FELDSTEIN ◽  
FRANK R. JOHNSON ◽  
CHARLES A. KALLICK ◽  
S ALEXANDER DOOLAS
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis

Acute hemorrhagic pancreatitis

1950 ◽  
Vol 17 (12) ◽  
pp. 409-410 ◽  
Author(s):  
William Saphir
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis

scholarly journals Studies on porcine pancreatic elastase activity. II. Immunoreactive elastase level during acute hemorrhagic pancreatitis in pigs.

1980 ◽  
Vol 131 (2) ◽  
pp. 127-134 ◽  
Author(s):  
YASUYUKI NAKAJIMA ◽  
SEIKI MATSUNO ◽  
NOBORU NOTO ◽  
YOICHI SAITOH ◽  
TOSHIO SATO
Keyword(s):  
Elastase Activity ◽  
Pancreatic Elastase ◽  
Hemorrhagic Pancreatitis ◽  
Porcine Pancreatic Elastase ◽  
Elastase Level ◽  
Acute Hemorrhagic Pancreatitis ◽  
Immunoreactive Elastase

THE TREATMENT OF ACUTE HEMORRHAGIC PANCREATITIS.

JAMA ◽  
1905 ◽  
Vol XLIV (17) ◽  
pp. 1372
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis

Injection of Microspheres into Pancreatic Arteries Causes Acute Hemorrhagic Pancreatitis in the Rat

Pancreas ◽  
1990 ◽  
Vol 5 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Falah Redha ◽  
Georg Uhlschmid ◽  
Rudolf W. Ammann ◽  
Andreas U. Freiburghaus
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis ◽  
Pancreatic Arteries

Acute Fatt- Liver of Pregnanc- with H-perlipidemia, Acute Hemorrhagic Pancreatitis and Disseminated Intravascular Coagulation

2010 ◽  
Vol 11 (3) ◽  
pp. 371-376 ◽  
Author(s):  
Hisanori Minakami ◽  
Kozo Kimura ◽  
Takashi Kanazawa ◽  
Taro Tamada ◽  
Kou Kaneko
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Intravascular Coagulation ◽  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis

scholarly journals ACUTE HEMORRHAGIC PANCREATITIS.

JAMA ◽  
1905 ◽  
Vol XLV (27) ◽  
pp. 2011
Author(s):  
C. F. NEW
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis
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