THE TREATMENT OF ACUTE HEMORRHAGIC PANCREATITIS.

JAMA ◽  
1905 ◽  
Vol XLIV (17) ◽  
pp. 1372
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis

THE SELECTIVE PROTEOLYTIC ENZYME INHIBITORY ACTION OF BENZETHONIUM CHLORIDE

1960 ◽  
Vol 38 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Ivan T. Beck ◽  
E. Pinter ◽  
R. D. McKenna ◽  
H. Griff
Keyword(s):  
Subcutaneous Injection ◽  
Proteolytic Enzyme ◽  
Inhibitory Action ◽  
Hemorrhagic Pancreatitis ◽  
Benzethonium Chloride ◽  
Tryptic Activity ◽  
High Concentrations ◽  
Acute Hemorrhagic Pancreatitis ◽  
Very High

Acute hemorrhagic pancreatitis in humans is thought to be perpetuated by the autolytic processes catalyzed by trypsin and lipase. This study is an integral part of our search for trypsin and lipase inhibitors to be used in the treatment of this disease.Benzethonium chloride was found to inhibit tryptic activity in vitro. The proteolytic activity of rabbit's serum was inhibited, and the inhibition was most pronounced 6 to 12 hours after the subcutaneous injection of the compound. Fibrinolysin was also inhibited in vitro but benzethonium chloride had no inhibitory action on chymotrypsin, pepsin, or lipase.Serum proteins in vitro were precipitated only with very high concentrations of the compound. No significant protein changes were observed in sera of rabbits after the subcutaneous injection of the compound.

scholarly journals Acute Hemorrhagic Pancreatitis and Pseudocyst Due to Mumps

1974 ◽  
Vol 180 (1) ◽  
pp. 85-88 ◽  
Author(s):  
JEFFREY D. FELDSTEIN ◽  
FRANK R. JOHNSON ◽  
CHARLES A. KALLICK ◽  
S ALEXANDER DOOLAS
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis

Injection of Microspheres into Pancreatic Arteries Causes Acute Hemorrhagic Pancreatitis in the Rat

Pancreas ◽  
1990 ◽  
Vol 5 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Falah Redha ◽  
Georg Uhlschmid ◽  
Rudolf W. Ammann ◽  
Andreas U. Freiburghaus
Keyword(s):  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis ◽  
Pancreatic Arteries

scholarly journals Porphyria Cutanea Tarda Associated With Acute Hemorrhagic Pancreatitis

2019 ◽  
Vol 7 ◽  
pp. 232470961985276
Author(s):  
Manasi Singh ◽  
Ashley Duckett ◽  
Marc Heincelman
Keyword(s):  
Abdominal Pain ◽  
Physical Examination ◽  
Community Hospital ◽  
Porphyria Cutanea Tarda ◽  
Acute Onset ◽  
Laboratory Evaluation ◽  
Hemorrhagic Pancreatitis ◽  
Acute Hemorrhagic Pancreatitis ◽  
Epigastric Abdominal Pain ◽  
New Onset

Porphyria cutanea tarda (PCT) is a condition of dysregulated heme synthesis that leads to accumulation of photosensitizing precursors with resultant fragility and blistering of the skin. It can be hereditary or acquired and has been known to be associated with hepatic C virus, alcohol, HIV, and estrogen. In this article, we report an unusual presentation of PCT associated with acute hemorrhagic pancreatitis in a 57-year-old man. He presented initially to a community hospital with acute onset of epigastric abdominal pain and new-onset ascites. Lipase was elevated. Diagnostic paracentesis was grossly bloody. He was then transferred to our institution for concern for acute hemorrhagic pancreatitis. On arrival, physical examination demonstrated vesicles and bullae with erythematous bases, in different stages of healing seen over the dorsal aspects of both hands with scaling, scarring, and hypopigmentation and hyperpigmentation of the skin. Laboratory evaluation and skin biopsy confirmed the diagnosis of PCT. Search for an underlying etiology failed to reveal typical predisposing factors. This report illustrates that acute hemorrhagic pancreatitis may be an underlying etiology for PCT.

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