Proteolytic Enzyme
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2021 ◽  
Vol 6 (4) ◽  
Imam Budiman ◽  
Farizky Wahyudi ◽  
Yunardi Yunardi ◽  
Hesti Meilina

Wet fermentation by added proteolytic enzyme can be used for upgrade the taste of coffee. The enzyme was obtained from plant because of ease to get and fulfill the term of Indonesia’s constitution about halal product assurance. This study used two types of proteolytic enzyme; bromelain and zingibain that originated from pineapple and ginger, respectively. Coffee beans were fermented with weight ratio 1:4 and 3:4 (enzyme’s source: coffee beans), and compared with a non-adding control and commercial coffee. Samples were collected after 1, 2 and 3 days. Roasted beans were physical and chemical evaluated according to Indonesia National Standard (SNI-01-3542-2004). Also, the sensorial evaluation of the roasted coffee beans was determined by organoleptic test. Physical and chemical evaluation consist of water content, ash content, coffee extract, ash alkalinity and caffeine content. Sensorial evaluation includes color, aroma and flavor.

2021 ◽  
pp. 34-37
Rajesh Dhadiwal ◽  
Shashank Tiwari ◽  
Ramendra Kumar Jauhari

Surgical care is an integral component of health systems, and so is the appropriate management of the surgical wound. Excessive inammation and edema, in the post-surgical period, can result in delayed wound healing, infective complications and increased length of hospital stay, among other complications. Systemic enzyme therapy (SET) with trypsin and bromelain, in combination with the bioavonoid rutoside, has been extensively investigated as alternatives to conventional therapies for pain and swelling associated with many inammatory conditions. The multi-pronged pharmacodynamic action of these ingredients on different inammatory processes has been highlighted in this review. Additionally, clinical studies demonstrating the benecial effects of SET in multiple surgical settings, including general surgical, dental, orthopaedic, cosmetic surgeries, are also discussed

Dr. S. E. Gowtham

Abstract: The point of the executives is to ease the pain rapidly and improve practical capacity. NSAIDs are the primary line treatment. Serratiopeptidase is the proteolytic enzyme. The challenge lies in deciding whether only NSAIDs or NSAIDs with proteolytic enzyme will give more prominent indicative help, while additionally being savvy. the primary goal is to think about the adequacy of diclofenac with paracetamol and diclofenac with serratiopeptidase in the administration of delicate tisssue injury. This prospective, open label, observational study was conducted at a tertiary care hospital. Patients over 18 years of age and presenting with soft tissue injury pain (elbow pain, knee pain, general pain, back pain ) of less than 6 weeks duration were enrolled in the study. Forty patients with soft tissue injury pain were randomized into two groups: Group A got diclofenac with paracetamol (50mg/325mg) double a day and Group B got diclofenac with serratiopeptidase (50mg/10mg) double a day for 1 week. The Numerical Rating Scale (NRS) determined the clinically significant results. The decrease in pain intensity in Group B was (MEAN= 3.76), while in Group A it was (MEAN= 3.93). The average cost-effectiveness ratio indicated that diclofenac wit paracetamol was the dominant treatment over diclofenac with serratiopeptidase. Therefore, diclofenacc with paracetamol was found to be the cost-effective option for soft tissue injury pain relief in for 1 week. Both diclofenac wit paracetamol and diclofenac with serratiopeptidase. were clinically effective in reducing the pain intensity and in improving functional ability. H owever, diclofenac wit paracetamol was found to be the cost-effective intervention. Keywords: Paracetamol, diclofenac, Serratiopeptidase, soft tissue injury, pain.

2022 ◽  
Vol 169 ◽  
pp. 104188
Isaac Balume ◽  
Birhanu Agumas ◽  
Mary Musyoki ◽  
Sven Marhan ◽  
Georg Cadisch ◽  

2021 ◽  
Vol 10 (4) ◽  
pp. 277-280
Satyabrata Kundu ◽  

Calotropis procera is considered as a medicinal plant belonging to the Asclepiadaceae family, surrounded throughout India and in other tropical areas. The common names of C. procera are Arka, Akanal, Madar, and Akanda. Based on the morphological characteristics, the leaves of C. procera is characterized as ovate, obovate, ovate-oblong or elliptical. The medicinal value or pharmacological properties of this plant are associated with its latex. C. procera leaves is said to be important antidote against snake bite, burning, rheumatism, mumps and bacterial infections. The phytochemical composition of leaf powder composed of cardenolides, steroids, tannins, glycosides, terpenoids, flavonoids, alkaloids and saponins. Phytochemical screening of bark also showed the presence of several secondary metabolites. Latex mainly contains calotropaine (cardiotoxic), a proteolytic enzyme and also contains a small percentage of nontoxic proteolytic enzyme, calotropin. The plant has several ecological importance including natural phytoremediation, improvement in soil quality. Mainly, C. procera has great importance throughout world for its great value

2021 ◽  
Vol 41 (7) ◽  
pp. 3213-3232

2021 ◽  
Vol 14 (2(52)) ◽  
pp. 46-59
Ksеnia Nikolaevna Gershonchik ◽  
Valentina Nikolaevna Babodey ◽  
Tatsiana Vyacheslavovna Shugaeva ◽  
Svetlana Nikolaevna Vislouhova ◽  
Svetlana Evgenievna Tomashevich

The article presents the main results of fundamental research carried out by specialists of the group for the confectionery industry of the technology confectionery and oil and fat products department in 2008–2020. The chemical composition and technological properties of soluble fibers — inulin and oligofructose, as well as the source of inulin — Jerusalem artichoke, have been studied, their optimal dosages in the manufacture of zephyr have been determined, allowing to achieve technological effects and enrich the finished product with food fibers. Studied the composition of the linen cake and its influence on the quality of biscuits. The optimal dosages of linen cake have been established to increase the nutritional and biological value of the biscuits. The possibility of using durum wheat flour in the manufacture of biscuits has been studied. Influence of proteolytic enzyme, sugar and fat on protein proteolysis in confectionary dough for production of soluble biscuits is studied. It is defined that sugar and fat reduce speed of protein proteolysis, at that sugar has more inactivate ability. Optimal quantity of proteolytic enzyme is 0,15 % to mass of wheat flour. The rheological properties of syrups based on sweeteners for muesli bars have been investigated. Established the ratio of maltitol and maltitol syrup in the recipe for muesli bars for diabetic nutrition.

2021 ◽  
Vol 22 (9) ◽  
pp. 4828
Olga V. Stepanenko ◽  
Maksim I. Sulatsky ◽  
Ekaterina V. Mikhailova ◽  
Olesya V. Stepanenko ◽  
Irina M. Kuznetsova ◽  

Proteolytic enzymes are known to be involved in the formation and degradation of various monomeric proteins, but the effect of proteases on the ordered protein aggregates, amyloid fibrils, which are considered to be extremely stable, remains poorly understood. In this work we study resistance to proteolytic degradation of lysozyme amyloid fibrils with two different types of morphology and beta-2-microglobulun amyloids. We showed that the proteolytic enzyme of the pancreas, trypsin, induced degradation of amyloid fibrils, and the mechanism of this process was qualitatively the same for all investigated amyloids. At the same time, we found a dependence of efficiency and rate of fibril degradation on the structure of the amyloid-forming protein as well as on the morphology and clustering of amyloid fibrils. It was assumed that the discovered relationship between fibrils structure and the efficiency of their degradation by trypsin can become the basis of a new express method for the analysis of amyloids polymorphism. Unexpectedly lower resistance of both types of lysozyme amyloids to trypsin exposure compared to the native monomeric protein (which is not susceptible to hydrolysis) was attributed to the higher availability of cleavage sites in studied fibrils. Another intriguing result of the work is that the cytotoxicity of amyloids treated with trypsin was not only failing to decline, but even increasing in the case of beta-2-microglobulin fibrils.

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