Abstract
Background: The reformulated simethicone emulsion from Berlin Chemical AG might develop white flocculate precipitation covering gastric mucosa when used before esophagogastroduodenoscopy (EGD). We aim to investigate whether combining reformulated simethicone emulsion with 5% NaHCO3 solution could prevent the development of white precipitation and improve visibility during EGD. Methods: Our study involved 523 patients. They were randomly assigned to two groups: In Group A patients received a warm mixed solution containing 30 ml 5% NaHCO3 solution and 15 ml reformulated simethicone emulsion. In Group B patients received 45 ml 40℃ lukewarm water. Visibility scores were recorded and analyzed. In addition, flush times, volume of flush water, overall time taken for EGD and complications during or after procedure were also recorded. Results: We found that no white precipitation was observed during EGD in Group A. Moreover, visibility scores in Group A were significantly lower (P < 0.01). Patients in Group A had fewer flush times (P < 0.01) and smaller volumes of flush water (P < 0.01). In addition, overall time taken for EGD procedure was significantly shorter in Group A (P < 0.01). The percentage of patients who had no adverse response is significantly higher in patients in Group A compared to Group B (P < 0.01). Conclusions: Premedication with mixed solution of 15ml reformulated simethicone emulsion and 30ml 5% NaHCO3 solution can prevent the development of white precipitation, substantially enhance mucosal visibility safely.Trial registration: The registered name of the trial is “Efficacy of using premedication with reformulated simethicone emulsion during upper gastrointestinal endoscopy examination”. Current Controlled Trials ChiCTR1900021689, as well as the date of registration is 11 September 2019. Retrospectively registered, http://www.medresman.org.cn/uc/sindex.aspx.
Effects of supplemental oxygen on cardiac rhythm during upper gastrointestinal endoscopy: a randomised controlled double blind trial.
