Comparing Golqand (Persian Medicine Product) with Magnesium Hydroxide in Adult Constipation: A Randomized Clinical Trial

Chronic constipation is a highly prevalent digestive problem in the community, which would decrease the quality of life of individuals. There is not any conclusive drug of choice for constipation. Golqand (combined Rosa × damascena Herrm. and honey) has been introduced as an effective safe laxative in Persian medicine (PM). This study aimed to investigate the effects of Golqand in comparison with Magnesium hydroxide suspension (MOM) in chronic constipation. In this clinical trial, fifty-six patients with chronic constipation were randomly assigned to the study groups of Golqand or MOM. Patients received Golqand (20 g daily) or MOM (40 mL daily) for 2 weeks. Patients took the drug twice a day, MOM group used it in the morning (20 mL) and at night before going to bed (20 mL). The Golqand group used it 10 g before lunch and 10 g before dinner, dissolved it in lukewarm water and swallowed. Then, they were followed for the second two weeks without any medication. The primary outcome was frequency of defecation. Patients were evaluated before the study and two weeks and four weeks after the beginning study. Estimated marginal mean frequency of defecation in the MOM group in the first two weeks was significantly higher than the Golqnd group (P < 0.05). There was no significant difference among the groups in the third week when treatment was discontinued (P = 0.155) but in the fourth week, the Golqand group had more count of defecation than the MOM group (P = 0.001). There was no significant difference between the two study groups in terms of treatment satisfaction and drug side effects (P > 0.05). Golqand medication can be used in the treatment of constipation with very few drug side effects and a more lasting effect than MOM drug.

A comparative clinical study of Khanda Shunthi and Prasarni Avaleha in the Management of Ama Vata w.s.r. to Rheumatoid Arthritis

Rheumatoid Arthritis is a chronic inflammatory joint disease characterized by swollen, painful and stiff joints. Amavata is a disease of Madhyama Roga Marga as it affects Sandhis and Haridaya Marma. Though Ama and Vata are the predominant pathogenic factors but the disease represents Tridoshic vitiation. The affliction of Sandhis by Vata dosha in association with Ama reflects the equal role of both Dosha and Dushya in the causation of disease. Moreover, the chief pathogenic factors, being contradictory in nature possess difficulty in planning the line of treatment. The objectives of this randomized parallel group comparative study were to evaluate the effect of Khanda Shunthi and Prasarni Avaleha in the management of Amavata. This Study was conducted on 40 patients selected randomly from OPD and IPD of Desh Bhagat Ayurvedic Hospital and divided into 2 trial groups A and B having 20 patients in each group. Group A received Khanda Shunthi 10 gms BD and Group B received Prasarni Avaleha 10 gms BD with lukewarm water for 60 days. Results showed statistically significant difference in effect of Group A and Group B on, Pain, Swelling, Stiffness, ESR, Walking time and Grip Strength except on Fever and HB. Percent wise Khanda Shunthi is found to be more effective than Prasarni Avaleha for all assessment criteria in the management of Amavata.

Method validation for determination of nine pesticides in okra and their mitigation using different solutions

In this paper we optimized QuEChERS method for extraction of nine pesticides viz. acephate, acetamiprid, chlorpyrifos, cypermethrin, imidacloprid, thiamethoxam, profenofos (insecticides), carbendazim and tebuconazole (fungicides) and performed their quantitative estimation in okra crop by HPLC-UV and GC-ECD. Decontamination treatments namely washing with running tap water, soaking in lukewarm water (50–60°C), soaking in solutions of 1% NaCl, 5% NaHCO3, 2% CH3COOH, 0.01% KMnO4 and three commercial formulations were also done for ten minutes every time, to calculate the extent of pesticide removal from okra. Results revealed that the proposed extraction method was efficient, inexpensive, accurate, rapid and precise and can suitably be used for the simultaneous quantitative determination of the above pesticides. The standard curve was linear over the concentration range of 0.05–5μg g-1 with R2 close to one (0.999). Soaking of okra in 2% acetic acid and then washing proved as the best decontamination treatments for all the pesticides. It showed the highest relative decontaminating capacity in comparison to the other solutions tested. Since the pesticide residues are usually present in higher amount in vegetables being consumed, it is of utmost importance to keep an eye over the use of pesticides to protect the crops.

A CLINICAL STUDY OF DEVDALI HIMA NASYA AND DRONPUSHPI SWARASA ANJANA IN KAMALA (JAUNDICE)

Most people have become used to spicy fast-food day by day. This has taken human beings far away from nature. Nowadays alcohol consumption is also increasing day by day. Ayurvedic texts have mentioned hepatocellular jaundice as Kamala. Due to frequent intake of Pittakara Aahara (spicy and hot food), it leads to vitiation of Pitta Dosha and Virechana1 (purgation) is the first line of treatment for Pittadushti. Ayurvedic line of management Ac- cording to lolimbraj (Vaidya jivana)2 i.e., Nasya therapy and According to Chakradatta Anjana3 therapy in addi- tion with above mentioned take 3 gm Triphala Churna with Lukewarm water at bedtime for Koshta shuddhi. Nasya and Anjana both are successful in Kamala by removing toxic waste from the body, and by correcting Agni (digestive fire). In our ancient classics, single drugs along with compound drugs have been mentioned in Kamala. These drugs have Kamalahara properties. This results in better circulation and nourishment of the organs and the diseases will subside. Kamala is a disease caused by an overabundance of Mala Ranjak Pitta. Nasya cleanses and energies the tissues and organs of the head and neck. Shodhan Nasya is a form of Nasya that promotes secretions and removes toxins from the body. Devadali Phal Nasya is a form of Shodhan, particularly Rechna Nasya, that causes accumulated Mala Ranjak Pitta to be excreted through the nose. Nasya is referred to as "Nastah Pracchar- dan" by Charaka4. It means Nasya is shodhan karma, which explains Nasya's position at the systemic level and why sr. bilirubin levels fall. Dronpushpi is Doşakarma Kaphavātaśamaka, Pittasamśodhaka Property.It is having Katu, Lavaņa, Madhura Rasa. It is laxative, angmintic, stimulant and febrifuge. The swarasa of this herb is ap- plied as a collyrium (natrănjana) in case of jaundice. Keywords: Jaundice, Kamala, Pitta Dushti, Nasya, Anjana, LFT.

Ayurvedic Management of Parikarthika (Acute Fissure in Ano) – A Case Study

Among anorectal diseases, Parikarthika (Fissure in ano) is considered one of the most painful diseases. Now a days the incidence rate of this disease became more due to the irregular food habits as well as unproper modern life style changes. Due to this its recent occurrence in all types of age groups irrespective of gender. This case study described the effective management of acute fissure in ano which was managed with ayurvedic treatment modalities. A 23-year male patient came with symptoms of pain and burning during and after defecation and also having the presence of blood streak while passing of stool. The patient was diagnosed as acute fissure due to the presence of a cut longitudinal ulcer in lower part of anal canal at the 6 o’clock position. Ayurvedic treatment approach both internally and externally were followed. Jatyadi Ghritham Pichu application followed by a lukewarm water sitz bath was advised as external treatment. The complete improvement was found in this within 12 days of treatment. No reoccurrence was noted even after 3rd month of follow up.

AYURVEDIC MANAGEMENT OF PARTIAL EMPTY SELLA SYNDROME: A CASE REPORT

Empty Sella Syndrome is a disorder that involves the presence of Cerebro-spinal fluid in Sella turcica in an excess amount. In empty Sella syndrome the Sella turcica is either partially filled with cerebrospinal fluid and an atrophied pituitary gland lying in the floor of the Sella (Partial Empty Sella Syndrome) or filled with cerebrospinal fluid which pushes the pituitary gland into a side of Sella turcica resulting in non-visualization of the gland. (Completely empty Sella). A 37-year-old female diagnosed with partial empty Sella syndrome was managed with Pathyakshadhatryadi kashayam 15 ml twice daily in empty stomach with 45 ml lukewarm water, Rasnadi choornam tailam application, mahatraiphala ghritam 10 ml at night after food, Kshirabala 7 Avarti tailam pratimarsha nasyam. After completion of the treatment, there was considerable relief in the primary complaint of the patient which was a recurrent headache and the follow up MRI showed a marked change in the condition. This case report highlights the role of Ayurveda in the management of partial empty Sella syndrome and sheds light for further study on the same.

Effect of Murivenna Ointment in the Management of Parikarthika (Acute Fissure in Ano) – A Pilot Study

Parikarthika (Fissure in ano) is one of the most painful condition which is occurring in the ano rectal region. Due to irregular food habits and modern life styles of peoples in the present era has also added to the increase in the rate of incidence of fissure in ano. The aim of the present pilot study was to assess the effectiveness of Murivenna ointment in the management of Parikarthika. This study was conducted in 22 patients diagnosed as acute fissure in ano. Patients Murivenna ointment was applied locally with digitally in fissure bed (Parikartika) of all 22 patients. All patients were advised to follow this twice daily after sitz bath for 4 weeks or till healing of fissure bed whichever is earlier. Adjuvant drug Triphalachurnam 5 gm orally at bedtime with lukewarm water was prescribed daily to all patients with constipation. There was significant relief in symptoms like pain in ano and bleeding per rectum in all patients after 30 days of treatment. The anal sphincter tonicity became normal in 21 patients (95.45%) after 30 days of treatment. Ulcer in ano was completely healed in 19 patients (86.36%) after 30 days of treatment. There was no reoccurrence in all patients after 30 days of follow up. The irritable symptoms like pain and bleeding per rectum were effectively relieved within 14 days of treatment in all patients. It is one of the effective treatments in the management of fissure in ano as it relieved the cardinal symptoms of fissure in ano such as cutting pain and burning pain.

A Clinical Study on Efficacy of Ajeya Ghrita in Dushivisha Janya Lakshana

In modern era or day to day life cumulative toxicity (Dushivisha) increases the need for antioxidants as the body attempts to neutralize the harmful substances. The factors such as Viruddhahara and Ahitahara, fast foods and cold beverages, alcohol, tobacco, pesticides, metals and pollutants etc. can be considered under Dushivisha (cumulative poison). Aggravate Dosha vitiate the Dhatu (elements of body) specially Rakta Dhatu, it deposits in body tissues due to mild potency in nature, it covered by Kapha dosha and produces many diseases in favorable condition. Acharya Sushruta in Kalp sthana mentioned Ajeya Ghrita as a best remedy for the management of Dushivisha derived diseases. The content of Ajeya ghrita have Laghu, Rukhsha, Tiksna, Katu, Ushna, Kushthaghna, Krimighana Vishghna and antioxidant properties can help the breakdown the pathogenesis of Dushi visha. This formulation is given in 30 patients which is divided in two group having 15 patients in each group in oral dose of 12gm BD with lukewarm water for 30 days with follow up 30 days. Patient having sign and symptoms of fever, Kotha (skin allergies), Kasa (cough), Trishna (increased thirst), abdominal pain, recurrent Avipaka (indigestion)/ Arochak (anorexia), recurrent Chardi (vomiting)/ nausea, recurrent Shirahshool (headache)/ dizziness, recurrent Jwara (fever), recurrent Atisara (diarrhea), premature aging (wrinkling of skin, greying and loss of hair etc.), Smritinasha (loss of memory), recurrent Daurbalya (weakness), result found 1 patient (6.67%) were completely remitted in Group A while group B not found. 4 patients (26.66%) Group A, while in Group B, 3 (20%) were moderately improved respectively. 5 patients (33.33%) were no relief in group A and 4 (40%) in group B, no relief in any symptoms.

A RANDOMIZED COMPARATIVE CLINICAL EVALUATION OF HARIDRADI LEHA AND VASADI KASHAYA IN THE MANAGEMENT OF TAMAKA SHWASA (BRONCHIAL ASTHMA)

Tamaka Shwasa in Ayurveda is analogous to Bronchial Asthma due to similarity in causative and precipitating factors, onset, pathogenesis and symptoms. An estimated 300 million people worldwide suffer from asthma, with 250,000 annual deaths attributed to the disease. The Objective is to evaluate and compare the efficacy of Haridradi Leha with and without Vasadi Kashaya in the management of Tamaka Shwasa. Total 30 patients were registered for the present study. The patients of group A were administered Haridradi Leha in a dose of 20 grams BD (Bis in die i.e., twice daily) in empty stomach orally with lukewarm water for 21 days. The patients of group B were administered Haridradi Leha (20 grams BD) and Vasadi Kashaya (50 ml BD) with Anupana (co-administers with medicine) of honey orally for 21 days. There are highly significant results (p value: p<0.01, p<0.001) in breathlessness, cough, body position, wheezing in a day, wheezing in night, heart rate in both group but quantity of sputum, respiratory rate, use of accessory muscle and mental status shows highly significant result only in Group B. Both groups have highly significant result in peak expiratory flow rate (PEFR) and forced expiratory volume in one second (FEV1). Both the Haridradi Leha and Vasadi Kashaya are highly effective in the management of Tamaka Shwasa. Haridradi Leha along with Vasadi Kashaya provided better relief than Haridradi Leha alone in most of the sign and symptom of the disease at significant level.

Role of Snigdha Virechana with Chinchalavan Taila in the Management of Malavastambha: A Case Report

Background: Malavastambha (Constipation) is defined as the infrequent and difficult passage of stool. The main features of Constipation are infrequent or hard stool, abdominal pain, bloating, and feeling of unsatisfactory bowel evacuation. Contemporary laxatives, which are generally used in Constipation, become habitual after some duration and only symptomatic relief. Moreover, these medicines never alter the pathogenesis of the disease. So, it is a need of hour to search effective, safe & alternative formulations in Ayurveda, which can completely break the pathogenesis of Constipation. As per Ayurveda, Vata Dosha is the main factor involved in this condition. Therefore, the prime treatment principle recommended by Ancient Acharyas is to pacify Vata by using Vatahara herbs medicated with Snigdha Dravya, Amla, and Lavana Varga. The Chincha Lavana Taila is one such combination that possesses the above principle & so; it can be effective in Malavastambha. Aim: This case study is primarily carried out to study the role of oral administration of Chincha Lavana Taila in Malavashtambha Objectives: To evaluate the efficacy of oral consumption of Chincha Lavana Taila in Malavastambha. Methods: A single case study. A 50 years old male patient approached Panchakarma O.P.D. with Malavsthambha for one year; he was advised to intake 15ml Chincha Lavana Taila orally at bedtime lukewarm water for consecutive 15 days. Observation and Results: The patient got 100% relief in his all chief & associated complaints and had regular and satisfactory bowel habits after 15 days. Conclusion: Chincha Lavana Taila is one of the best effective oral medicine for Constipation.