scholarly journals Glucocorticoid regulation in rat brain cell cultures. Hydrocortisone increases the rate of synthesis of glycerol phosphate dehydrogenase in C6 glioma cells.

1978 ◽  
Vol 253 (23) ◽  
pp. 8483-8492
Author(s):  
J.F. McGinnis ◽  
J. de Vellis
2019 ◽  
Vol 60 ◽  
pp. 281-292
Author(s):  
Domitille Schvartz ◽  
Víctor González-Ruiz ◽  
Nadia Walter ◽  
Paola Antinori ◽  
Fabienne Jeanneret ◽  
...  

1991 ◽  
Vol 73 (2-3) ◽  
pp. 21a-21a ◽  
Author(s):  
S. Marret ◽  
B. Delpech ◽  
H. Levesque ◽  
A. Delpech ◽  
S.-X. Ma ◽  
...  

2015 ◽  
Vol 30 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Jessica J.W. Broeders ◽  
Joop L.M. Hermens ◽  
Bas J. Blaauboer ◽  
Marie-Gabrielle Zurich

2014 ◽  
Vol 230 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Jenny Sandström von Tobel ◽  
Debora Zoia ◽  
Jorane Althaus ◽  
Paola Antinori ◽  
Julien Mermoud ◽  
...  

2017 ◽  
Vol 39 (4) ◽  
pp. 258-263 ◽  
Author(s):  
L D Liubich ◽  
L M Kovalevska ◽  
M I Lisyany ◽  
V M Semenova ◽  
T A Malysheva ◽  
...  

The aim of the work was to study the impact of fetal rat brain cell supernatant (FRBCS) on the expression of transforming growth factor β1 (TGF-β1) and p53 in C6 cells of rat glioma in vitro. Materials and Methods: FRBCS was obtained from suspensions of fetal rat brain cells on the 14th (E14) day of gestation. C6 glioma cells were cultured for 48 h in the presence of FRBCS or FRBCS + anti-TGF-β1 monoclonal antibody. Immunocytochemical staining for TGF-β1 and p53 was performed. Results: The proportion of TGF-β1-immunopositive tumor cells in C6 glioma cultures was statistically significantly higher than in the control cell cultures of normal fetal rat brain. FRBCS reduced the proportion of TGF-β1-immunopositive tumor cells and increased the proportion of p53-immunopositive cells in C6 glioma cultures. In cells cultured with FRBCS + anti-TGF-β1 monoclonal antibody, the above effects of FRBCS were abrogated. Conclusion: The obtained results suggest that TGF-β1 seems to be responsible for decrease in TGF-β1 expression and increase in p53 expression in C6 glioma cells treated with FRBCS.


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