Early- and late-onset obsessive–compulsive disorder in adult patients: an exploratory clinical and therapeutic study

Background. Age at onset (AAO) has been useful to explore the clinical, neurobiological and genetic heterogeneity of obsessive–compulsive disorder (OCD). However, none of the various thresholds of AAO used in previous studies have been validated, and it remains an unproven notion that AAO is a marker for different subtypes of OCD. If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics.Method. Admixture analysis was used to determine the best-fitting model for the observed AAO of 161 OCD patients.Results. The observed distribution of AAO in OCD is a mixture of two Gaussian distributions with mean ages of 11·1±4·1 and 23·5±11·1 years. The first distribution, defined by early-onset OCD, had increased frequency of Tourette's syndrome and increased family history of OCD. The second distribution, defined by late-onset OCD, showed elevated prevalence of general anxiety disorder and major depressive disorder.Conclusions. These results, based on a statistically validated AAO cut-off and those of previous studies on AAO in OCD, suggest that AAO is a crucial phenotypic characteristic in understanding the genetic basis of this disorder.

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Neuropsychological profiles of patients with obsessive-compulsive disorder: early onset versus late onset

Journal of the International Neuropsychological Society ◽

10.1017/s1355617707070063 ◽

2006 ◽

Vol 13 (01) ◽

Cited By ~ 23

Author(s):

SEON HEE HWANG ◽

JUN SOO KWON ◽

YONG-WOOK SHIN ◽

KYUNG JIN LEE ◽

YOUNG YOUN KIM ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Early Onset ◽

Late Onset ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Meta-Analysis of the Dose–Response Relationship of SSRIs in Adult Patients with Obsessive-Compulsive Disorder

10.1093/med/9780190625085.003.0030 ◽

2018 ◽

Author(s):

Eunice Yuen ◽

Michael H. Bloch

Keyword(s):

Obsessive Compulsive Disorder ◽

Meta Analysis ◽

Adult Patients ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

American Psychiatry ◽

American Psychiatry Association ◽

Relationship Of ◽

Study Intervention

This chapter provides a summary of a landmark study on adult patients with obsessive-compulsive disorder (OCD). Discussion here is based on a meta-analysis from nine prominent clinical studies. Are there any differences in efficacy and tolerability among different doses of, selective serotonin reuptake inhibitor in the treatment of OCD? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and American Psychiatry Association (APA) guideline information, discusses implications, and concludes with a relevant clinical case.

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