1641 A case series of metformin related vitamin B12 deficiency in diabetes elderly correlated with neurological manifestations

2005 ◽  
Vol 238 ◽  
pp. S516
Keyword(s):  
Vitamin B12 ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
B12 Deficiency

scholarly journals Subacute combined degeneration of the spinal cord in functional vitamin B12 Deficiency states

2021 ◽  
Vol 20 (4) ◽  
pp. 21-23
Author(s):  
Christina Englezou ◽  
◽  
Di Liang ◽  
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Cognitive Deficits ◽  
Metabolic Pathways ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
Subacute Combined Degeneration ◽  
Ability To Act ◽  
B12 Deficiency

Vitamin B12 is an essential enzymatic cofactor in multiple cellular metabolic pathways. Deficiency states can arise as a result of both depletion of absolute systemic levels and pathological processes that block its ability to act as an enzymatic cofactor. The latter is also known as functional vitamin B12 deficiency. This can cause a variety of systemic, haematological, and neurological manifestations, some of which may be irreversible if not promptly treated. Neurological syndromes include subacute combined degeneration of the cord (SCDC), peripheral, optic, and autonomic neuropathies, and neuropsychiatric or cognitive deficits. This review presents a case series of vitamin B12 deficiencies leading to SCDC, and we include the clinical features, significant investigations, treatments, and prognoses.

Neuropsychological Profiles of Children Following Vitamin B12 Deficiency During Infancy: A Case Series

2016 ◽  
Vol 17 (3) ◽  
pp. 242-253
Author(s):  
M. Greenham ◽  
V. Anderson ◽  
J. Campbell ◽  
P. Monagle ◽  
M.H. Beauchamp
Keyword(s):  
Vitamin B12 ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Brain Maturation ◽  
Attention And Memory ◽  
Long Term Outcomes ◽  
Retrospective Case ◽  
School Aged Children ◽  
B12 Deficiency

Previous studies investigating long-term outcomes in children following vitamin B12 deficiency during infancy have been limited to IQ or clinical observation. This paper seeks to describe comprehensive neuropsychological profiles in a case series of school-aged children who were treated for infantile vitamin B12 deficiency. This was a retrospective case series of seven children who were treated for vitamin B12 deficiency during infancy and aged 5 to 16 years at the time of testing. While most children had age-expected intellectual performance, the distribution of the sample was skewed to the lower end of the normal range. Furthermore, children were found to have impairments in a number of neuropsychological domains, most common were attention and memory, followed by executive function. These results suggest that while neurological symptoms quickly resolve following treatment, these effects on early brain development may disrupt brain maturation and have the potential to impact on later development.

scholarly journals Biochemical Impedance on Intracellular Functions of Vitamin B12 in Chronic Toxigenic Mold Exposures

2007 ◽  
Vol 7 ◽  
pp. 1649-1657 ◽  
Author(s):  
Ebere C. Anyanwu ◽  
Ijeoma Kanu
Keyword(s):  
Vitamin B12 ◽  
Neurological Disorders ◽  
Vitamin B12 Deficiency ◽  
Methionine Synthase ◽  
Neurological Manifestations ◽  
Biochemical Processes ◽  
B12 Deficiency ◽  
Spinal Degeneration ◽  
One Carbon Metabolism ◽  
And Function

A majority of patients with neurological disorders with chronic exposures to toxigenic molds and mycotoxins has vitamin B12 deficiency that is unrelated to dietary insufficiency. Vitamin B12 is a source of coenzymes, and participates in intracellular recycling of methionine, and in methionine synthase reactions. The biochemical processes that lead to B12 depletion and deficiency are not fully understood. This paper examines and assesses various most likely biochemical reasons that could impede upon the normal intracellular functions of vitamin B12 that lead to neurological manifestations. By biochemical implications and derivations, it is most likely that mycotoxins interrupt the structure and function of vitamin B12 through reactive interference with the normal One-Carbon metabolism leading to the observed clinical neurological manifestations such as nerve damage and, demyelination, degeneration of PNS leading to paralysis, progressive peripheral neuropathy, and spinal degeneration.

Vitamin B12 deficiency in infants secondary to maternal deficiency: A case series of seven infants

2017 ◽  
Vol 21 ◽  
pp. e3 ◽  
Author(s):  
A. Fadilah ◽  
R. Musson ◽  
M.T. Ong ◽  
A.V. Desurkar ◽  
S.R. Mordekar
Keyword(s):  
Vitamin B12 ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals Manifestações neurológicas em decorrência da carência de cianocobalamina (Vitamina B12): Um relato de caso / Neurological manifestations due to cyanocobalamin (Vitamin B12) deficiency: a case report

2021 ◽  
Vol 4 (5) ◽  
pp. 18562-18564
Author(s):  
Gianott Oliveira Celeste ◽  
Marina Pinheiro Bezerra Justo ◽  
Maria Eduarda Cabral Crispim ◽  
Clara Campêlo Lucena Vieira ◽  
Lara Beatriz Viana Freitas Costa
Keyword(s):  
Case Report ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
B12 Deficiency

scholarly journals KNUCKLE HYPERPIGMENTATION AS A PRELIMINARY MARKER OF VITAMIN B 12 DEFICIENCY: A CASE SERIES

2021 ◽  
pp. 36-38
Author(s):  
Manali Patil ◽  
S. N. Agrawal ◽  
V. V. Saoji
Keyword(s):  
Vitamin B12 ◽  
Megaloblastic Anemia ◽  
Case Series ◽  
Vitamin B12 Deficiency ◽  
Neurological Deficits ◽  
Vitamin B ◽  
Important Clue ◽  
B12 Deficiency ◽  
Systemic Manifestations ◽  
Vitamin B 12

Vitamin B12 deficiency is common in vegetarian population in India and can present with variable Hematological (megaloblastic anemia), Neuropsychiatric, Mucocutaneous (glossitis, angular stomatitis), Skin (pallor, hyperpigmentation) and Hair changes (dry, brittle, thin, lustreless, prematurely grey). Knuckle hyperpigmentation has been described in vitamin B12 deficiency but usually these patients are dermatologically asymptomatic but they have systemic manifestations like megaloblastic anemia, pancytopenia or neurological deficits. The foreground of this study is highlighting the importance of knuckle hyperpigmentation as an early cutaneous sign of vitamin B12 deficiency which points an important clue towards the aetiology of Megaloblastic anemia.

scholarly journals VITAMIN B12 DEFICIENCY; FREQUENCY OF NEUROLOGICAL MANIFESTATIONS IN QUETTA

2017 ◽  
Vol 24 (06) ◽  
pp. 878-887
Author(s):  
IRFANA HASSAN ◽  
BHAGWAN DAS ◽  
SANTOSH KUMAR ◽  
GHULAM HAIDER KHALID ◽  
ABDUL MANAN JUNEJO ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Neurological Manifestations ◽  
B12 Deficiency
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