1108: Treatment Strategy Improves the in Vivo Stone Comminution Efficiency and Reduces Renal Tissue Injury During Shock Wave Lithotripsy

2005 ◽  
Vol 173 (4S) ◽  
pp. 300-301
Author(s):  
Michaella E. Maloney ◽  
Pei Zhong ◽  
Charles G. Marguet ◽  
Yufeng F. Zhou ◽  
Jeffrey C. Sung ◽  
...  
Keyword(s):  
Shock Wave ◽  
Treatment Strategy ◽  
Shock Wave Lithotripsy ◽  
Tissue Injury ◽  
Renal Tissue

1115: The Effect of Treatment Strategy on Stone Comminution Efficiency in Shock Wave Lithotripsy

2004 ◽  
Vol 171 (4S) ◽  
pp. 294-294
Author(s):  
Yufeng Zhou ◽  
Charles G. Marguet ◽  
Michaella E. Maloney ◽  
Franklin H. Cocks ◽  
Glenn M. Preminger ◽  
...  
Keyword(s):  
Shock Wave ◽  
Treatment Strategy ◽  
Shock Wave Lithotripsy ◽  
Effect Of Treatment

Resolution of renal inflammation: a new role for NF-κB1 (p50) in inflammatory kidney diseases

2009 ◽  
Vol 297 (2) ◽  
pp. F429-F439 ◽  
Author(s):  
Ulf Panzer ◽  
Oliver M. Steinmetz ◽  
Jan-Eric Turner ◽  
Catherine Meyer-Schwesinger ◽  
Claudia von Ruffer ◽  
...  
Keyword(s):  
Tissue Injury ◽  
Kidney Diseases ◽  
Renal Tissue ◽  
Induction Phase ◽  
Nuclear Compartment ◽  
Renal Inflammation ◽  
Proinflammatory Gene ◽  
And Function ◽  
Proinflammatory Gene Expression

In renal tissue injury, activation of the transcription factor NF-κB has a central role in the induction of proinflammatory gene expression, which are involved in the development of progressive renal inflammatory disease. The function of NF-κB during the switch from the inflammatory process toward resolution, however, is largely unknown. Therefore, we assessed the time-dependent activation and function of NF-κB in two different models of acute nephritis. Our experiments demonstrate a biphasic activation of NF-κB in the anti-Thy-1 model of glomerulonephritis in rats and the LPS-induced nephritis in mice, with a first peak during the induction phase and a second peak during the resolution period. After induction of glomerular immune injury in rats, predominantly NF-κB p65/p50 heterodimer complexes are shifted to the nucleus whereas during the resolution phase predominantly p50 homodimers could be demonstrated in the nuclear compartment. In addition, we could demonstrate that p50 protein plays a pivotal role in the resolution of LPS-induced renal inflammation since NF-κB p50 knockout mice demonstrate significantly higher chemokine expression, prolonged renal inflammatory cell infiltration with consecutive tissue injury, and reduced survival. In conclusion, our studies indicate that NF-κB subunit p50 proteins have critical in vivo functions in immunologically mediated renal disease by downregulating inflammation during the resolution period.

IN VIVO ASSESSMENT OF FREE RADICAL ACTIVITY DURING SHOCK WAVE LITHOTRIPSY USING A MICRODIALYSIS SYSTEM:

2002 ◽  
pp. 327-334 ◽  
Author(s):  
RAVI MUNVER ◽  
FERNANDO C. DELVECCHIO ◽  
RAMSAY L. KUO ◽  
SPENCER A. BROWN ◽  
PEI ZHONG ◽  
...  
Keyword(s):  
Shock Wave ◽  
Free Radical ◽  
Shock Wave Lithotripsy ◽  
Free Radical Activity ◽  
In Vivo Assessment

IN VIVO ASSESSMENT OF FREE RADICAL ACTIVITY DURING SHOCK WAVE LITHOTRIPSY USING A MICRODIALYSIS SYSTEM: THE RENOPROTECTIVE ACTION OF ALLOPURINOL

2002 ◽  
Vol 167 (1) ◽  
pp. 327-334 ◽  
Author(s):  
RAVI MUNVER ◽  
FERNANDO C. DELVECCHIO ◽  
RAMSAY L. KUO ◽  
SPENCER A. BROWN ◽  
PEI ZHONG ◽  
...  
Keyword(s):  
Shock Wave ◽  
Free Radical ◽  
Shock Wave Lithotripsy ◽  
Free Radical Activity ◽  
In Vivo Assessment

Innovative Piezoelectric Extracorporeal Lithotripter

2008 ◽  
pp. 745-753
Author(s):  
Achim M. Loske ◽  
Francisco Fernández ◽  
Gilberto Fernández
Keyword(s):  
Shock Wave ◽  
Shock Waves ◽  
Kidney Stones ◽  
Open Surgery ◽  
Shock Wave Lithotripsy ◽  
Renal Tissue ◽  
The Body ◽  
Extracorporeal Shock Wave ◽  
Tissue Trauma ◽  
Salivary Gland Stones

Before 1980, the majority of patients with urolithiasis and nephrolithiasis needed surgery (Kerbl, Rehman, Landman, Lee, Sundaram, & Clayman, 2002; Soucie et al., 1994). Fortunately, percutaneous nephrolithotomy, ureteroscopic intrarenal surgery, laparoscopic surgery, and extracorporeal shock wave lithotripsy (SWL) now allow almost any calculus to be removed without open surgery. SWL refers to the use of high intensity pressure pulses, generated outside the body, to break up kidney stones (Chaussy, Brendel, & Schmiedt, 1980; Loske, 2007). It has become the standard treatment for the majority of patients and an alternative in the management of gallbladder stones, pancreatic concrements, and salivary gland stones. Even though initial studies concluded that shock waves had no damaging effect on renal tissue, later several authors reported that shock waves may cause tissue trauma (Evan, Willis, Connors, McAteer, & Lingeman, 1991; Evan, Willis, & Lingeman, 2003 Willis et al., 1999). Fortunately, techniques and devices are still evolving and improvements to increase stone fragmentation efficiency and reduce tissue trauma are being constantly sought.

scholarly journals Comparison of Tissue Injury from Focused Ultrasonic Propulsion of Kidney Stones Versus Extracorporeal Shock Wave Lithotripsy

2014 ◽  
Vol 191 (1) ◽  
pp. 235-241 ◽  
Author(s):  
Bret A. Connors ◽  
Andrew P. Evan ◽  
Philip M. Blomgren ◽  
Ryan S. Hsi ◽  
Jonathan D. Harper ◽  
...  
Keyword(s):  
Shock Wave ◽  
Kidney Stones ◽  
Extracorporeal Shock Wave Lithotripsy ◽  
Shock Wave Lithotripsy ◽  
Tissue Injury ◽  
Extracorporeal Shock Wave ◽  
Ultrasonic Propulsion
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