Direct enantioselective synthesis of syn-1,3-diols by the reaction of aldehydes with enol silyl ethers in the presence of a chiral borane complex. Successive asymmetric aldol reaction and asymmetric reduction with one promoter

1994 ◽  
Vol 35 (24) ◽  
pp. 4107-4110 ◽  
Author(s):  
Yuichi Kaneko ◽  
Takao Matsuo ◽  
Syun-ichi Kiyooka
Keyword(s):  
Asymmetric Reduction ◽  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Silyl Ethers ◽  
Asymmetric Aldol Reaction ◽  
Enol Silyl Ethers

scholarly journals Enantioselective synthesis of (−)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction

2016 ◽  
Vol 14 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Allegra Franchino ◽  
Pavol Jakubec ◽  
Darren J. Dixon
Keyword(s):  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
Catalytic Asymmetric

A concise synthesis of (−)-chloramphenicol, based on the catalytic asymmetric aldol reaction between 4-nitrobenzaldehyde and benzhydryl isocyanoacetate, is reported.

scholarly journals Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 648
Author(s):  
Yu-Hao Zhou ◽  
Yu-Zu Zhang ◽  
Zhu-Lian Wu ◽  
Tian Cai ◽  
Wei Wen ◽  
...  
Keyword(s):  
Primary Amine ◽  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction ◽  
Aldol Addition ◽  
High Yields

A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.

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