A new method for the synthesis of optically pure phosphine oxides

1985 ◽  
Vol 26 (6) ◽  
pp. 783-786 ◽  
Author(s):  
Tsuneo Imamoto ◽  
Kazuhiko Sato ◽  
Carl R. Johnson
Keyword(s):  
New Method ◽  
Phosphine Oxides ◽  
Optically Pure

Preparation of Optically Pure Tertiary Phosphine Oxides via the Addition ofP-Stereogenic Secondary Phosphine Oxide to Activated Alkenes

2016 ◽  
Vol 81 (17) ◽  
pp. 7644-7653 ◽  
Author(s):  
Ji-Ping Wang ◽  
Shao-Zhen Nie ◽  
Zhong-Yang Zhou ◽  
Jing-Jing Ye ◽  
Jing-Hong Wen ◽  
...  
Keyword(s):  
Phosphine Oxide ◽  
Secondary Phosphine ◽  
Phosphine Oxides ◽  
Tertiary Phosphine ◽  
Optically Pure

ChemInform Abstract: NEW METHOD FOR THE REDUCTION OF SULFOXIDES, SULFONES, AND PHOSPHINE OXIDES BY LOW-VALENCE COMPLEXES OF TITANIUM

1980 ◽  
Vol 11 (32) ◽  
Author(s):  
U. M. DZHEMILEV ◽  
L. YU. GUBAIDULLIN ◽  
G. A. TOLSTIKOV ◽  
L. M. ZELENOVA
Keyword(s):  
New Method ◽  
Phosphine Oxides

New method for synthesis of bifunctional tertiary phosphine oxides

1973 ◽  
Vol 22 (12) ◽  
pp. 2677-2680
Author(s):  
V. K. Khairullin ◽  
G. V. Dmitrieva ◽  
I. A. Aleksandrova ◽  
M. A. Vasyanina
Keyword(s):  
New Method ◽  
Phosphine Oxides ◽  
Tertiary Phosphine

Enantioselective, Copper-Catalyzed Addition of Nucleophilic Silicon to Alkenyl-Substituted Phosphine Oxides

Synthesis ◽  
2021 ◽  
Author(s):  
Dou Hong ◽  
Wenbin Mao ◽  
Elisabeth Irran ◽  
Martin Oestreich
Keyword(s):  
Phosphine Oxide ◽  
New Method ◽  
Phosphine Oxides ◽  
Copper Salts

An enantioselective β-silylation of α,β-unsaturated phosphine oxide derivatives using a silylboronic ester as the silicon pronucleophile is reported. The reaction is catalyzed by copper salts in the presence of chiral pyridine–oxazoline (PyOx) ligands. Good to high enantioselectivities (≤ 95% ee) are obtained for β-aryl-substituted acceptors whereas alkyl residues in the β-position lead to a lower ee value for 1° and no reaction for 2° and 3°. The new method represents another way of accessing α-chiral silanes and complements the known β-borylation.

Mechanistic aspects of the stereospecific reduction of chiral hydroxyalkyl phosphinates and phosphine oxides

2016 ◽  
Vol 88 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Sébastien Lemouzy ◽  
Duc Hanh Nguyen ◽  
David Gatineau ◽  
Laurent Giordano ◽  
Damien Hérault ◽  
...  
Keyword(s):  
Secondary Phosphine ◽  
Phosphine Oxides ◽  
Stereospecific Reduction ◽  
Recent Advances ◽  
Optically Pure ◽  
By Products

AbstractWe present recent advances in the understanding of the reduction of optically pure hydroxyalkylphosphinates and phosphine oxides, which represent key intermediates for the preparation of P-stereogenic ligands. Their reduction leads to P-chiral phosphinites and phosphines, respectively, and occurs stereospecifically with inversion of configuration using BH3·THF, which plays three roles: activating, reducing and protecting agent. The formation of by-products as hydroxyalkyl secondary phosphine–boranes has also been studied.

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