Mechanistic aspects of the stereospecific reduction of chiral hydroxyalkyl phosphinates and phosphine oxides
Keyword(s):
AbstractWe present recent advances in the understanding of the reduction of optically pure hydroxyalkylphosphinates and phosphine oxides, which represent key intermediates for the preparation of P-stereogenic ligands. Their reduction leads to P-chiral phosphinites and phosphines, respectively, and occurs stereospecifically with inversion of configuration using BH3·THF, which plays three roles: activating, reducing and protecting agent. The formation of by-products as hydroxyalkyl secondary phosphine–boranes has also been studied.
2016 ◽
Vol 81
(17)
◽
pp. 7644-7653
◽
Keyword(s):
2016 ◽
Vol 191
(11-12)
◽
pp. 1480-1481
◽
Keyword(s):
Keyword(s):
Keyword(s):