Chapter 6 GABAA Receptor Function and Gene Expression During Pregnancy and Postpartum

2009 ◽  
pp. 73-94 ◽  
Author(s):  
Giovanni Biggio ◽  
Maria Cristina Mostallino ◽  
Paolo Follesa ◽  
Alessandra Concas ◽  
Enrico Sanna
Keyword(s):  
Gene Expression ◽  
Gabaa Receptor ◽  
Receptor Function ◽  
Pregnancy And Postpartum

Social isolation-induced increase in alpha4 and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAA receptor function

2006 ◽  
Vol 98 (1) ◽  
pp. 122-133 ◽  
Author(s):  
Mariangela Serra ◽  
Maria Cristina Mostallino ◽  
Giuseppe Talani ◽  
Maria Giuseppina Pisu ◽  
Mario Carta ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gabaa Receptor ◽  
Social Isolation ◽  
Receptor Function ◽  
Subunit Gene ◽  
Delta Subunit

scholarly journals Flumazenil selectively prevents the increase in α4-subunit gene expression and an associated change in GABAA receptor function induced by ethanol withdrawal

2007 ◽  
Vol 102 (3) ◽  
pp. 657-666 ◽  
Author(s):  
Francesca Biggio ◽  
Giorgio Gorini ◽  
Stefania Caria ◽  
Luca Murru ◽  
Enrico Sanna ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gabaa Receptor ◽  
Ethanol Withdrawal ◽  
Receptor Function ◽  
Subunit Gene

scholarly journals Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Valentina Licheri ◽  
Giuseppe Talani ◽  
Ashish A. Gorule ◽  
Maria Cristina Mostallino ◽  
Giovanni Biggio ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Gabaa Receptors ◽  
Postpartum Period ◽  
Neuronal Excitability ◽  
Receptor Expression ◽  
Neuroactive Steroids ◽  
Receptor Function ◽  
Pregnancy And Postpartum ◽  
Sudden Decrease ◽  
New Treatments

Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a crucial role in neuronal excitability by local modulation of specific inhibitory receptors: the GABAA receptors. Marked fluctuations in both blood and brain concentration of neuroactive steroids strongly contribute to GABAA receptor function and plasticity. In this review, we listed several interesting results regarding the regulation and plasticity of GABAA receptor function during pregnancy and postpartum period in rats. The increase in brain levels of neuroactive steroids during pregnancy and their sudden decrease immediately before delivery are causally related to changes in the expression/function of specific GABAA receptor subunits in the hippocampus. These data suggest that alterations in GABAA receptor expression and function may be related to neurological and psychiatric disorders associated with crucial periods in women. These findings could help to provide potential new treatments for these women’s disabling syndromes.

Changes in GABAA receptor gene expression induced by withdrawal of, but not by long-term exposure to, zaleplon or zolpidem

2002 ◽  
Vol 42 (2) ◽  
pp. 191-198 ◽  
Author(s):  
P Follesa ◽  
L Mancuso ◽  
F Biggio ◽  
E Cagetti ◽  
M Franco ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gabaa Receptor ◽  
Receptor Gene ◽  
Receptor Gene Expression

GABAA Receptor Subunit Gene Expression in Human Prefrontal Cortex: Comparison of Schizophrenics and Controls

1995 ◽  
Vol 5 (6) ◽  
pp. 550-560 ◽  
Author(s):  
Schahram Akbarian ◽  
Molly M. Huntsman ◽  
James J. Kim ◽  
Alireza Tafazzoli ◽  
Steven G. Potkin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Gabaa Receptor ◽  
Receptor Subunit ◽  
Subunit Gene
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