Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling

1995 ◽  
Vol 76 (3) ◽  
pp. S158-S162 ◽  
Author(s):  
Arthur Weiss
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Tyrosine Kinases ◽  
Cell Receptor ◽  
Protein Tyrosine Kinases ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals Interaction between CD45-AP and Protein-tyrosine Kinases Involved in T Cell Receptor Signaling

1999 ◽  
Vol 274 (3) ◽  
pp. 1407-1414 ◽  
Author(s):  
Satoshi Motoya ◽  
Koichi Kitamura ◽  
Akio Matsuda ◽  
Abby L. Maizel ◽  
Hiroyuki Yamamoto ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Tyrosine Kinases ◽  
Cell Receptor ◽  
Protein Tyrosine Kinases ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

Cell ◽  
1991 ◽  
Vol 65 (2) ◽  
pp. 281-291 ◽  
Author(s):  
Michael P. Cooke ◽  
Kristin M. Abraham ◽  
Katherine A. Forbush ◽  
Roger M. Perimutter
Keyword(s):  
T Cell ◽  
Tyrosine Kinase ◽  
T Cell Receptor ◽  
Protein Tyrosine Kinase ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
Family Protein ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals Suppressors of T-cell Receptor Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of Receptor Tyrosine Kinases

2004 ◽  
Vol 279 (31) ◽  
pp. 32786-32795 ◽  
Author(s):  
Katarzyna Kowanetz ◽  
Nicola Crosetto ◽  
Kaisa Haglund ◽  
Mirko H. H. Schmidt ◽  
Carl-Henrik Heldin ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 ◽  
Vol 182 (5) ◽  
pp. 1585-1590 ◽  
Author(s):  
N S van Oers ◽  
H von Boehmer ◽  
A Weiss
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Tyrosine Kinases ◽  
Cell Receptor ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine ◽  
Zeta Chain ◽  
Proximal Signaling ◽  
Zeta Chains

The pre-T cell receptor (TCR) complex regulates early T cell development and consists of a heterodimer of the TCR-beta subunit in association with the pre-TCR-alpha chain. Notably, in contrast to alpha/beta-expressing T cells, several studies suggested that the TCR-zeta chain is not stably associated with this pre-TCR complex. To examine the proximal signaling processes mediated by the pre-TCR complex and the role of the TCR-zeta chain in these processes, we stimulated pre-TCR-expressing cells and analyzed the interactions of the TCR/CD3 invariant chains with the Syk/ZAP-70 family of protein tyrosine kinases. Stimulation of the pre-TCR complex led to the tyrosine phosphorylation of the CD3 epsilon and TCR-zeta chains, as well as the phosphorylation and association of ZAP-70 and Syk with phosphorylated CD3 epsilon and TCR-zeta. These results demonstrate that the pre-TCR complex is functionally coupled to the TCR-zeta subunit and to the ZAP-70 and Syk protein tyrosine kinases.

scholarly journals The Role of a Lymphoid-restricted, Grb2-like SH3-SH2-SH3 Protein in T Cell Receptor Signaling

1997 ◽  
Vol 272 (2) ◽  
pp. 894-902 ◽  
Author(s):  
Thomas Trüb ◽  
J. Daniel Frantz ◽  
Masaya Miyazaki ◽  
Hamid Band ◽  
Steven E. Shoelson
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling

Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling

2006 ◽  
Vol 18 (1) ◽  
pp. 105-122 ◽  
Author(s):  
Alexandre K. Rouquette-Jazdanian ◽  
Claudette Pelassy ◽  
Jean-Philippe Breittmayer ◽  
Claude Aussel
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling
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