scholarly journals HYPOTHERMIC ANALGESIA FOR OPEN HEART SURGERY WITH THE HEART-LUNG MACHINE

1959 ◽  
Vol 37 (2) ◽  
pp. 184-189 ◽  
Author(s):  
William W. Musicant ◽  
Reuben R. Lewis ◽  
Belmont S. Musicant ◽  
Robert M. Anderson ◽  
Jerome Harold Kay
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Heart Lung Machine ◽  
Lung Machine

scholarly journals Clinical Experience of Open-heart Surgery by Means of Hypothermia and Heart-lung Machine

1964 ◽  
Vol 83 (2) ◽  
pp. 146-158 ◽  
Author(s):  
Togo Horiuchi ◽  
Kei Koyamada ◽  
Takeo Honda ◽  
Takeshi Ishitoya ◽  
Yasuhiko Sagawa ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Heart Lung Machine ◽  
Lung Machine

Pioneering Open-Heart Surgery at the University of Minnesota and the Mayo Clinic

2015 ◽  
Author(s):  
W. Bruce Fye
Keyword(s):  
Congenital Heart ◽  
Heart Surgery ◽  
Heart Defects ◽  
Open Heart Surgery ◽  
Clinical Use ◽  
Open Heart ◽  
University Of Minnesota ◽  
Heart Lung Machine ◽  
The University ◽  
Lung Machine

During the early 1950s, several dozen surgeons were attempting to develop technologies and techniques that would allow them to operate inside the heart. The challenge was to develop a safe way to temporarily take over the functions of the heart and lungs so the heart could be opened and drained of blood. A surgeon could then see and repair abnormal or damaged structures inside the organ. The first patients were children or adolescents with congenital heart defects that had caused heart failure. Mayo surgeon John Kirklin led a multidisciplinary team in the testing and clinical use of a heart-lung machine that had been refined in Rochester from plans provided by IBM and John Gibbon Jr. of Philadelphia. Although initial mortality was high, experience with the Mayo-Gibbon machine proved that it was possible to operate inside the hearts and save the lives of patients who were destined to die without surgery.

scholarly journals Lorazepam in Open-Heart Surgery — Plasma concentrations before, during and after bypass following different dose regimens

1984 ◽  
Vol 12 (1) ◽  
pp. 9-13 ◽  
Author(s):  
M. J. Boscoe ◽  
S. Dawling ◽  
M. A. Thompson ◽  
R. M. Jones
Keyword(s):  
Oral Dose ◽  
Heart Surgery ◽  
Plasma Concentrations ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Additional Weight ◽  
Heart Lung Machine ◽  
Lung Machine

Thirty-six patients (29 males and 7 females) undergoing open-heart surgery received one of three different dose regimens of lorazepam. All received a weight-related oral dose (2 mg, 3 mg or 4 mg) pre-operatively for night sedation. Twenty-four patients had an additional weight-related dose (2 mg, 3 mg or 4 mg intravenously) either as part of the induction (12 patients) or just prior to connection of the heart-lung machine (12 patients). Plasma concentrations of lorazepam were measured 20 minutes after induction, immediately before bypass, 30 and 60 on bypass and 30 minutes after bypass. Only when additional intravenous lorazepam was given prior to connection to the heart-lung machine were plasma lorazepam concentrations obtained compatible with complete amnesia.

Design Optimization of a Wearable Artificial Pump-Lung Device With Computational Modeling

2010 ◽  
Author(s):  
M. Ertan Taskin ◽  
Tao Zhang ◽  
Bartley P. Griffith ◽  
Zhongjun J. Wu
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Computational Modeling ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Traditional System ◽  
Clinical Complications ◽  
Multiple Components ◽  
Heart Lung Machine ◽  
Lung Machine

The heart-lung machine has been commonly used to replace or supplement the functions of both the heart and lung in the open heart surgery and extracorporeal membrane oxygenation (ECMO). Although ECMO devices are efficient on respiratory support, this traditional system consists of multiple components and is bulky. Furthermore, ECMO devices are associated with clinical complications as well as the necessity of being confined to the bed. To eliminate these, we aimed to design and develop a wearable artificial pump lung (APL) device.

scholarly journals Novel Straight Type Aortic Cannula with Spiral Flow Inducing Design

2015 ◽  
Vol 773-774 ◽  
pp. 69-74 ◽  
Author(s):  
Nofrizalidris Darlis ◽  
Nadia Shaira Shafii ◽  
Jeswant Dillon ◽  
Kahar Osman ◽  
Ahmad Zahran Md Khudzari
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Ascending Aorta ◽  
Spiral Flow ◽  
Heart Lung Machine ◽  
Atherosclerosis Development ◽  
Aortic Cannula ◽  
Major Factors ◽  
Novel Design ◽  
Lung Machine

Aortic cannula is one of major factors leading to adverse events such as thrombosis and atherosclerosis development during open heart surgery. This is due to oxygenated blood outflow with high velocity jet from heart lung machine when exiting the cannula tip into ascending aorta. It was discovered, and validated by several researchers that blood flow out of the left ventricle into the aorta is spiral in nature. In this study, a novel design in which internal profile of the cannula was made to induce spiral flow were tested by way of numerical simulation, and compared against existing commercial cannula. Three designs were tested, which differed in number of groove employed. Among the cannula model designs, cannula design with 4 grooves yielded the lowest value of maximum wall shear stress at testing tube with 3.778 Pa and highest value of area weighted helicity density at 40 mm from cannula tips with 11.829 m/s2. Overall, spiral cannula models were showed highly potential in inducing spiral flow, and also the effect on blood hemolysis is acceptable.

Sign in / Sign up

Export Citation Format

Share Document