COVID MED - An Early Pandemic Trial of Losartan for Hospitalized COVID-19 Patients

Background ACEi/ARB medications have been hypothesized to have potential benefit in COVID-19. Despite concern for increased ACE-2 expression in some animal models, preclinical and observational-retrospective and uncontrolled trials suggested possible benefit. Two RCTs of the ARB losartan from University of Minnesota showed no benefit yet safety signals for losartan in outpatient and hospitalized COVID-19 patients. COVID MED, started early in the pandemic, also assessed losartan in a RCT in hospitalized patients with COVID-19. Methods COVID MED was quadruple-blinded, placebo-controlled, multicenter randomized clinical trial (RCT). Hospitalized COVID-19 patients were randomized to receive standard care and hydroxychloroquine, lopinavir/ritonavir, losartan, or placebo. Hydroxychloroquine and lopinavir/ritonavir arms were discontinued after RCTs showed no benefit. We report data from the losartan arm compared to combined (lopinavir-ritonavir and placebo) and prespecified placebo-only controls. The primary endpoint was the NCOSS slope of change. Slow enrollment prompted early stopping. Results Of 432 screened patients, 14 were enrolled (3.5%), 9 received losartan and 5 combined control (lopinavir/ritonavir [N=2], placebo [N=3]); 1 hydroxychloroquine arm patient was excluded. Most baseline parameters were balanced. Treatment with losartan was not associated with a difference in NCOSS slope of change in comparison with combined control (p=0.4) or placebo-only control (p=0.05) (trend favoring placebo). 60-day mortality and overall AE and SAE rates were numerically but not significantly higher with losartan. Conclusions In this small blinded RCT in hospitalized COVID-19 patients, losartan did not improve outcome vs. control comparisons and was associated with adverse safety signals.

Relating Ndesign to Field Compaction: A Case Study in Minnesota

High field density helps in increasing the durability of asphalt pavements. In a current research effort, the University of Minnesota and the Minnesota Department of Transportation (MnDOT) have been working on designing asphalt mixtures with higher field densities. One critical issue is the determination of the Ndesign values for these mixtures. The physical meaning of Ndesign is discussed first. Instead of the traditional approach, in which Ndesign represents a measure of rutting resistance, Ndesign is interpreted as an indication of the compactability of mixtures. The field density data from some recent Minnesota pavement projects are analyzed. A clear negative correlation between Ndesign and field density level is identified, which confirms the significant effect of Ndesign on the compactability and consequently on the field density of mixtures. To achieve consistency between the laboratory and field compaction, it is proposed that Ndesign should be determined to reflect the real field compaction effort. A parameter called the equivalent number of gyrations to field compaction effort (Nequ) is proposed to quantify the field compaction effort, and the Nequ values for some recent Minnesota pavement projects are calculated. The results indicate that the field compaction effort for the current Minnesota projects evaluated corresponds to about 30 gyrations of gyratory compaction. The computed Nequ is then used as the Ndesign for a Superpave 5 mixture placed in a paving project, for which field density data and laboratory performance test results are obtained. The data analysis shows that both the field density and pavement performance of the Superpave 5 mixture are significantly improved compared with the traditional mixtures. The results indicate that Nequ provides a reasonable estimation of field compaction effort, and that Nequ can be used as the Ndesign for achieving higher field densities.

Hacked Transmissions: Technology and Connective Activism in Italy, Alessandra Renzi (2020)

Review of: Hacked Transmissions: Technology and Connective Activism in Italy, Alessandra Renzi (2020) Minneapolis: University of Minnesota Press, 256 pp., ISBN 978-1-51790-326-8, p/bk, $27.00

Clocking Out: The Machinery of Life in 1960s Italian Cinema, Karen Pinkus (2020)

Review of: Clocking Out: The Machinery of Life in 1960s Italian Cinema, Karen Pinkus (2020) Minnesota: University of Minnesota Press, 157 pp., ISBN 978-1-51790-854-6, p/bk, £18.99

Frontenac Gris as colour-mutant Frontenac grape variety

The work aimed to assess the cultivation and breeding prospects of the new Frontenac Gris technical grape variety obtained in 2003 by clonal selection as a colour-mutant Frontenac red technical grape originated by the University of Minnesota, USA. The variety is a complex cross-species hybrid with early maturity in the zone of Novocherkassk, Rostov Region. The variety was studied in 2018-2020 following the common viticulture and winemaking protocols at an experimental plot of the Novocherkassk trial field of All-Russian Research Institute of Viticulture and Winemaking named after Ya.I. Potapenko — Branch of the Federal Rostov Agricultural Research Centre. Vineyards were uncovered, unirrigated, grafted, Berlandieri×Riparia Kober 5BB rootstock, 3×1.5 m planting scheme. Formation as medium-standard double-shouldered horizontal cordon. By combination of economic value and agrobiological traits (cold and winter hardiness, yield, anti-phytopathogen resistance, high wine material quality), the Frontenac Gris variety holds promise in industrial viticulture. It can be recommended for gardening in sufficiently humid cool climates avoiding winter bush sheltering, as well as for breeding. The variety is low-hardy to drought and summer heat, which hinders its growing in the southern country. The variety’s disadvantages are in early maturity and slight berries wilting on bush in dry and windy air, which can pose an issue in juice production from pressed berries.

Matthew K. Gold and Lauren Klein, Eds., Debates in the Digital Humanities 2019

A review of Matthew K. Gold and Lauren Klein, Eds., Debates in the Digital Humanities 2019. Minneapolis: University of Minnesota Press, 2019. 472pp.

James J. Hodge, Sensations of History: Animation and New Media Art

A review of James J. Hodge, Sensations of History: Animation and New Media Art. Minneapolis: University of Minnesota Press, 2019. 232 pp. $27.00.