High sequence homology of the PrP gene in mule deer and Rocky Mountain elk

The Lancet ◽  
1997 ◽  
Vol 350 (9072) ◽  
pp. 219-220 ◽  
Author(s):  
Larisa Cervenáková ◽  
Robert Rohwer ◽  
Elizabeth S Williams ◽  
Paul Brown ◽  
D Carleton Gajdusek
1999 ◽  
Vol 80 (10) ◽  
pp. 2765-2679 ◽  
Author(s):  
K. I. O’Rourke ◽  
T. E. Besser ◽  
M. W. Miller ◽  
T. F. Cline ◽  
T. R. Spraker ◽  
...  

The PrP gene encodes the putative causative agent of the transmissible spongiform encephalopathies (TSEs), a heterogeneous group of fatal, neurodegenerative disorders including human Creutzfeldt–Jakob disease, bovine spongiform encephalopathy, ovine scrapie and chronic wasting disease (CWD) of North American deer and elk. Polymorphisms in the PrP gene are associated with variations in relative susceptibility, pathological lesion patterns, incubation times and clinical course of TSEs of humans, mice and sheep. Sequence analysis of the PrP gene from Rocky Mountain elk showed only one amino acid change (Met to Leu at cervid codon 132). Homozygosity for Met at the corresponding polymorphic site (Met to Val) in humans (human codon 129) predisposes exposed individuals to some forms of Creutzfeldt–Jakob disease. In this study, Rocky Mountain elk homozygous for PrP codon 132 Met were over-represented in both free- ranging and farm-raised CWD-affected elk when compared to unaffected control groups.


2003 ◽  
Vol 117 (2) ◽  
pp. 316 ◽  
Author(s):  
Robert M. Stephens ◽  
A. William Alldredge ◽  
Gregory E. Phillips

We documented four aggressive interactions between Rocky Mountain Elk (Cervus elaphus) and Mule Deer (Odocoileus hemionus) during the Elk calving season of June and July 1995. In one case, we believe a fawn Mule Deer was killed by two cow Elk. In the other three cases, Elk chased Mule Deer away from an area where they were grazing. These incidents are of interest because documentation of such interactions between Elk and Mule Deer is sparse in the scientific literature and because of the concern about declining Mule Deer populations throughout the western United States.


2003 ◽  
Vol 84 (3) ◽  
pp. 1076-1088 ◽  
Author(s):  
Alan A. Ager ◽  
Bruce K. Johnson ◽  
John W. Kern ◽  
John G. Kie

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