HIGH FREQUENCY OF EPSTEIN-BARR VIRUS GENOME IN HIV-POSITIVE PATIENTS WITH HODGKIN'S DISEASE

The Lancet ◽  
1989 ◽  
Vol 333 (8652) ◽  
pp. 1458 ◽  
Author(s):  
Stefania Uccini ◽  
Francesca Monardo ◽  
LuigiP. Ruco ◽  
CarloD. Baroni ◽  
Alberto Faggioni ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
High Frequency ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Virus Genome ◽  
Hiv Positive ◽  
Barr Virus ◽  
Epstein Barr

High frequency of Epstein-Barr virus genome detection in Hodgkin's disease of HIV-positive patients

1990 ◽  
Vol 46 (4) ◽  
pp. 581-585 ◽  
Author(s):  
Stefania Uccini ◽  
Francesca Monardo ◽  
Antonella Stoppacciaro ◽  
Angela Gradilone ◽  
Anna M. Aglianò ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
High Frequency ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Virus Genome ◽  
Hiv Positive ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Detection of free circulating Epstein-Barr virus DNA in plasma of patients with Hodgkin’s disease

2006 ◽  
Vol 124 (3) ◽  
pp. 154-157 ◽  
Author(s):  
Juliane Garcez Musacchio ◽  
Maria da Glória da Costa Carvalho ◽  
José Carlos Oliveira de Morais ◽  
Nathalie Henriques Silva ◽  
Adriana Scheliga ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Rio De Janeiro ◽  
Epstein Barr Virus ◽  
Advanced Disease ◽  
Hodgkin’S Disease ◽  
Hiv Positive ◽  
Control Group ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

CONTEXT AND OBJECTIVE: Free circulating Epstein-Barr virus (EBV) DNA is often present in the plasma of Hodgkin’s disease patients. The aim here was to evaluate the prevalence of this finding, its correlation with the immunohistochemical expression of LMP-1 (latent membrane protein 1) and the influence of other clinical factors. DESIGN AND SETTING: Prospective study in two public tertiary institutions: Hematology Service, Universidade Federal do Rio de Janeiro, and Oncology Service, Instituto Nacional do Câncer, Rio de Janeiro. METHODS: A cohort of 30 patients with newly diagnosed Hodgkin’s disease was studied. The control group consisted of 13 healthy adult volunteers. EBV DNA was determined by conventional polymerase chain reaction (PCR). RESULTS: The median age was 28 years, and 16 patients were women. Advanced disease was present in 19 patients, and six were HIV-positive. EBV DNA was present in the plasma of 13 patients and one control (43% versus 8%, p = 0.03). EBV DNA prevalence was higher in HIV-positive patients (100% versus 29%, p = 0.0007) and those with advanced disease (63% versus 9%, p = 0.006). Among HIV-negative patients alone, EBV DNA prevalence remained higher in those with advanced disease. EBV DNA was found in 10/11 patients with LMP-1 expression in the lymph nodes, and in 3/19 without LMP-1 expression (kappa coefficient = 0.72). CONCLUSION: EBV DNA was present in 91% of patients with EBV-associated Hodgkin’s disease, and in all patients with HIV-associated Hodgkin’s disease. EBV DNA prevalence was higher in patients with advanced disease, irrespective of HIV status.

Influence of Epstein–Barr Virus Genomes on Patient Survival in Hodgkin’s Disease

1992 ◽  
Vol 98 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Christian Fellbaum ◽  
Martin-Leo Hansmann ◽  
Hans Niedermeyer ◽  
Irmgard Kraus ◽  
Martti J. Alavaikko ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Patient Survival ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Genomes

Comparison of Epstein-Barr Virus Markers in Reed-Sternberg Cells in Adult Hodgkin's Disease Tissues from an Industrialized and a Developing Country

1995 ◽  
Vol 17 (1-2) ◽  
pp. 163-168 ◽  
Author(s):  
Mohammed I. Belkaid ◽  
Josette Briegre ◽  
Zahia Djebbara ◽  
Kheira Beldjord ◽  
Jean Marie Andrieu ◽  
...  
Keyword(s):  
Developing Country ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr
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