The SATE pronucleotide approach applied to acyclovirPart II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo

1999 ◽  
Vol 40 (3) ◽  
pp. 179-187 ◽  
Author(s):  
O HANTZ ◽  
C PERIGAUD ◽  
C BOREL ◽  
C JAMARD ◽  
F ZOULIM ◽  
...  
1989 ◽  
Vol 29 (4) ◽  
pp. 244-248 ◽  
Author(s):  
Hideaki Haritani ◽  
Toshikazu Uchida ◽  
Yasunori Okuda ◽  
Toshio Shikata

2001 ◽  
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Béatrice Seignères ◽  
Stéphanie Aguesse-Germon ◽  
Christian Pichoud ◽  
Isabelle Vuillermoz ◽  
Catherine Jamard ◽  
...  

1990 ◽  
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pp. 212-218 ◽  
Author(s):  
Jianzhang Niu ◽  
Yanyan Wang ◽  
Ming Qiao ◽  
Eric Gowans ◽  
Patrick Edwards ◽  
...  

1996 ◽  
Vol 40 (3) ◽  
pp. 792-794 ◽  
Author(s):  
P Hafkemeyer ◽  
A Keppler-Hafkemeyer ◽  
M A al Haya ◽  
M von Janta-Lipinski ◽  
E Matthes ◽  
...  

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.


1991 ◽  
Vol 15 ◽  
pp. 131
Author(s):  
Tim Shaw ◽  
Scott Bowden ◽  
Yanyan Wang ◽  
Gilda Civitico ◽  
Stephen Locarnini

2015 ◽  
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HONGYU JIA ◽  
CHANGHONG LIU ◽  
YING YANG ◽  
HAIHONG ZHU ◽  
FENG CHEN ◽  
...  

1992 ◽  
Vol 18 (2) ◽  
pp. 127-138 ◽  
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Andrew Shead ◽  
Karen Vickery ◽  
Aniko Pajkos ◽  
Robert Medhurst ◽  
John Freiman ◽  
...  

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