Molecular cloning of the 22–24 kDa excretory-secretory 22U protein of Dirofilaria immitis and other filarial nematode parasites

1999 ◽  
Vol 98 (2) ◽  
pp. 297-302 ◽  
Author(s):  
GlennR. Frank ◽  
Nancy Wisnewski ◽  
KevinS. Brandt ◽  
CliveR.D. Carter ◽  
NicolaS. Jennings ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Dirofilaria Immitis ◽  
Filarial Nematode ◽  
Nematode Parasites

Resistance of filarial nematode parasites to oxidative stress

1998 ◽  
Vol 28 (9) ◽  
pp. 1315-1332 ◽  
Author(s):  
Murray E. Selkirk ◽  
Vincent P. Smith ◽  
G.Ruth Thomas ◽  
Kleoniki Gounaris
Keyword(s):  
Oxidative Stress ◽  
Filarial Nematode ◽  
Nematode Parasites

scholarly journals A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites

BMC Genomics ◽  
2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Alan D Winter ◽  
Victoria Gillan ◽  
Kirsty Maitland ◽  
Richard D Emes ◽  
Brett Roberts ◽  
...  
Keyword(s):  
Filarial Nematode ◽  
Developmental Transitions ◽  
Nematode Parasites ◽  
Microrna Family

scholarly journals A proline-rich structural protein of the surface sheath of larval Brugia filarial nematode parasites

1991 ◽  
Vol 266 (17) ◽  
pp. 11002-11008
Author(s):  
M.E. Selkirk ◽  
M. Yazdanbakhsh ◽  
D. Freedman ◽  
M.L. Blaxter ◽  
E. Cookson ◽  
...  
Keyword(s):  
Filarial Nematode ◽  
Structural Protein ◽  
Nematode Parasites

scholarly journals Molecular cloning of an immunodominant antigen of Onchocerca volvulus.

1988 ◽  
Vol 168 (3) ◽  
pp. 1199-1204 ◽  
Author(s):  
R Lucius ◽  
N Erondu ◽  
A Kern ◽  
J E Donelson
Keyword(s):  
Adult Worm ◽  
Molecular Cloning ◽  
Dirofilaria Immitis ◽  
Cdna Sequence ◽  
Brugia Malayi ◽  
Recombinant Antigen ◽  
Onchocerca Volvulus ◽  
Structural Protein ◽  
Immunodominant Antigen

We have cloned and characterized the gene for an immunodominant antigen of O. volvulus that is recognized by the sera of 96% of patients with onchocerciasis. Its 1.2-kb mRNA constitutes 0.3% of adult worm poly(A)+ RNA and its cDNA sequence reveals that it is not a highly conserved structural protein such as actin or tubulin. Similar but not identical genes occur in the genomes of related filarie, Brugia malayi and Dirofilaria immitis. The recombinant antigen has both immunodiagnostic and immunoprophylactic significance.

The effect of invertebrate hormones and potential hormone inhibitors on the third larval moult of the filarial nematode, Dirofilaria immitis, in vitro

Parasitology ◽  
1993 ◽  
Vol 107 (4) ◽  
pp. 459-463 ◽  
Author(s):  
E. V. Warbrick ◽  
G. C. Barker ◽  
H. H. Rees ◽  
R. E. Howells
Keyword(s):  
Dirofilaria Immitis ◽  
Filarial Nematode ◽  
Similar Concentration ◽  
The Third ◽  
Insect Hormones ◽  
Filarial Nematodes ◽  
Ecdysteroid Agonists ◽  
Larval Moult

SUMMARYThe effects of the insect hormones, ecdysone and 20-hydroxyecdysone, certain non-steroidal ecdysteroid agonists (RH compounds) and the inhibitor, azadirachtin, on the timing of the 3rd-stage moult of Dirofilaria immitis were investigated. 20-Hydroxyecdysone and RH 5849 when used at a concentration of 10−5 M, resulted in a premature timing of this moult. Azadiracthin, at a similar concentration, prevented moulting of most of the larvae to the 4th stage. The results are discussed in relation to the possibility of a hormonal role for ecdysteroids and neuropeptide-like compounds in the control of ecdysis in filarial nematodes, that maybe somewhat comparable to the system which is found in insects.

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