Striatal dopaminergic transmission and neocortical glucose utilization in Alzheimer's disease: a triple-tracer positron emission tomography study

2000 ◽  
Vol 31 (2) ◽  
pp. 147-158 ◽  
Author(s):  
Kenichi Meguro ◽  
Satoshi Yamaguchi ◽  
Masumi Shimada ◽  
Masatoshi Itoh ◽  
Atsushi Yamadori
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Glucose Utilization ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Dopaminergic Transmission ◽  
Positron Emission

scholarly journals The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography

1987 ◽  
Vol 7 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Norman L. Foster ◽  
Abraham F. L. VanDerSpek ◽  
Michael S. Aldrich ◽  
Stanley Berent ◽  
Richard H. Hichwa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Metabolic Activity ◽  
Glucose Utilization ◽  
Activity Level ◽  
Emission Tomography ◽  
Positron Emission ◽  
Intravenous Diazepam

The effect of sedation induced by intravenous diazepam on cerebral glucose metabolic activity was examined with [18F]2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) in five patients with probable Alzheimer's disease. Each subject was studied on 2 separate days: on one occasion at rest with eyes patched and ears open, and on the second when sedated with intravenous diazepam titrated to maintain stage II sleep by clinical and EEG criteria. Similar patterns of glucose uptake were observed in both the presence and the absence of sedation, but overall glucose utilization was depressed an average of 20% and was closely correlated with the amount of diazepam administered prior to the injection of FDG. The predominant temporoparietal hypometabolism and relative sparing of frontal metabolism observed in this disease are therefore not explained by differences in anxiety or activity level in this patient group. Utilization of diazepam sedation for PET study appears to be safe and may permit the study of patients otherwise unable to cooperate with FDG-PET procedures.

scholarly journals Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

2013 ◽  
Vol 34 (1) ◽  
pp. 128-136 ◽  
Author(s):  
Alie Schuitemaker ◽  
Marc A. Kropholler ◽  
Ronald Boellaard ◽  
Wiesje M. van der Flier ◽  
Reina W. Kloet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Microglial Activation ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission

Amyloid load and cerebral atrophy in Alzheimer's disease: An11C-PIB positron emission tomography study

2006 ◽  
Vol 60 (1) ◽  
pp. 145-147 ◽  
Author(s):  
Hilary A. Archer ◽  
Paul Edison ◽  
David J. Brooks ◽  
Jo Barnes ◽  
Chris Frost ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Cerebral Atrophy ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission ◽  
Amyloid Load
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