PP-093 IDENTIFICATION OF LYMPHOCYTE POPULATIONS AND CARDIOVASCULAR FACTORS IN PERICARDIAL FLUID AND BLOOD SAMPLES AMONG PATIENTS UNDERGOING OPEN HEART SURGERY

2012 ◽  
Vol 155 ◽  
pp. S129-S130
Author(s):  
O. Gilicze ◽  
D. Simon ◽  
T. Berki ◽  
L. Czirják ◽  
S. Szabados ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Pericardial Fluid ◽  
Open Heart ◽  
Blood Samples ◽  
Lymphocyte Populations

scholarly journals L-arginine and Asymmetric Dimethylarginine (ADMA) levels in pericardial fluid in patients undergoing open heart surgery

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P3895-P3895
Author(s):  
A. Koller ◽  
A. Cziraki ◽  
S. Szabados ◽  
B. Biri ◽  
S. Keki ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Asymmetric Dimethylarginine ◽  
Open Heart Surgery ◽  
Pericardial Fluid ◽  
Open Heart

scholarly journals Population Pharmacokinetic Model for Vancomycin Used in Open Heart Surgery: Model-Based Evaluation of Standard Dosing Regimens

2018 ◽  
Vol 62 (7) ◽  
Author(s):  
Saeed A. Alqahtani ◽  
Abdullah S. Alsultan ◽  
Hussain M. Alqattan ◽  
Ahmed Eldemerdash ◽  
Turki B. Albacker
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Central Compartment ◽  
Volume Of Distribution ◽  
Peripheral Compartment ◽  
Population Pharmacokinetic ◽  
Albumin Concentration ◽  
Open Heart ◽  
Blood Samples ◽  
Dosing Regimens

ABSTRACTThe purpose of this study was to investigate the population pharmacokinetics of vancomycin in patients undergoing open heart surgery. In this observational pharmacokinetic study, multiple blood samples were drawn over a 48-h period of intravenous vancomycin in patients who were undergoing open heart surgery. Blood samples were analyzed using an Architect i4000SR immunoassay analyzer. Population pharmacokinetic models were developed using Monolix 4.4 software. Pharmacokinetic-pharmacodynamic (PK-PD) simulations were performed to explore the ability of different dosage regimens to achieve the pharmacodynamic targets. A total of 168 blood samples were analyzed from 28 patients. The pharmacokinetics of vancomycin are best described by a two-compartment model with between-subject variability in clearance (CL), the volume of distribution of the central compartment (V1), and volume of distribution of the peripheral compartment (V2). The CL and theV1of vancomycin were related to creatinine CL (CLCR), body weight, and albumin concentration. Dosing simulations showed that standard dosing regimens of 1 and 1.5 g failed to achieve the PK-PD target of AUC0–24/MIC > 400 for an MIC of 1 mg/liter, while high weight-based dosing regimens were able to achieve the PK-PD target. In summary, the administration of standard doses of 1 and 1.5 g of vancomycin two times daily provided inadequate antibiotic prophylaxis in patients undergoing open heart surgery. The same findings were obtained when 15- and 20-mg/kg doses of vancomycin were administered. Achieving the PK-PD target required higher doses (25 and 30 mg/kg) of vancomycin.

Activated Coagulation Time (ACT) Differences between Arterial and Venous Blood Samples in Patients with Open Heart Surgery

1997 ◽  
Vol 33 (3) ◽  
pp. 463 ◽  
Author(s):  
Byung Moon Ham ◽  
Yong Lak Kim ◽  
Sang Chul Lee ◽  
Jin Ho Lee ◽  
Myung Hee Kim ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Venous Blood ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Coagulation Time ◽  
Blood Samples ◽  
Activated Coagulation Time

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

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