1161 poster FDG PET IN LOCALLY ADVANCED HEAD-AND-NECK CANCER: THE PREDICTION VALUE OF METABOLIC TUMOUR VOLUME

Abstract Aim: Little is known about how integrated positron emission tomography-computed tomography (IPET-CT), both imaging tools and not methods of treatment, contributes to head and neck cancer patients’ outcomes. We analysed the clinical PET-CT findings and their correlation to the effects of applied contemporary disease management. Methodology: A retrospective analysis of 29 individuals who underwent treatment planning fusion of PET-CT for radiochemotherapy of locally advanced head and neck cancer between 2010 and 2016 was undertaken. Gross tumour volumes were categorised as small (≤36 cm3) or large (>36 cm3), and tumour responses to therapy were classified as complete or incomplete. Results: The overall rates of complete tumour response (CTR), 3-year crude survival and failure (all types included) were 80%, 41% and 55%, respectively. Comparative analysis of tumour volume subsets revealed no significant differences in the rates of CTR (p > 0.80), 3-year survival (p > 0.30) and locoregional recurrence (p > 0.70). CTR was associated with improved prognosis (p > 0.05) and fewer tumour relapses (p < 0.02). Conclusion: Our findings, although not truly conclusive, appear in line with those in the literature. Smaller tumour volumes and CTRs shown on integrated PET-CT are likely to play important roles in the promotion of better prognosis, but further study with larger patient numbers and more data are needed.

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The Prognostic Utility of 18F-FDG-PET Metabolic Tumor Response After Chemoradiation Therapy for Locally Advanced Head and Neck Cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2015.12.182 ◽

2016 ◽

Vol 94 (4) ◽

pp. 927

Author(s):

F.L. Ampil ◽

G. Caldito ◽

S. Devarakonda ◽

C. Reiser ◽

C.A.O. Nathan ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Fdg Pet ◽

Tumor Response ◽

Locally Advanced ◽

Chemoradiation Therapy ◽

Advanced Head ◽

Prognostic Utility ◽

18F Fdg

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TU-D-207B-03: Early Assessment of Response to Chemoradiotherapy Based On Textural Analysis of Pre and Mid-Treatment FDG-PET Image in Locally Advanced Head and Neck Cancer

Medical Physics ◽

10.1118/1.4957511 ◽

2016 ◽

Vol 43 (6Part34) ◽

pp. 3750-3751

Author(s):

Y Cui ◽

E Pollom ◽

B Loo ◽

Q Le ◽

W Hara ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Fdg Pet ◽

Locally Advanced ◽

Textural Analysis ◽

Advanced Head ◽

Early Assessment

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Impact of FDG-PET/CT on restaging and response evaluation of locally advanced head and neck cancer patient management

Journal of Radiotherapy in Practice ◽

10.1017/s1460396921000200 ◽

2021 ◽

pp. 1-10

Author(s):

Rabab A Moneim ◽

Emmad Habib ◽

Radfan Nagi ◽

M Yasser ◽

Moustafa Aldaly

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Fdg Pet ◽

Locally Advanced ◽

Advanced Head ◽

Response Evaluation ◽

Pet Ct ◽

Fdg Pet Ct ◽

Conventional Ct

Abstract Background: Head and neck cancer (HNC) accounts for 5% of all new cancer cases and most were locally advanced. Positron emission tomography/computed tomography (PET/CT) in radiotherapy practice in locally advanced head and neck squamous cell carcinoma (HNSCC) is being used in staging and proper contouring. Proper staging is essential for accurate treatment decision. Methods: This is a prospective phase II study conducted as a single institute centre to evaluate the role of PET/CT-treatment in staging, contouring and response evaluation of 30 patients with locally advanced HNSCC in contrast to CT scan. Our cases did not undergo radical surgery for the primary tumour, and biopsy was taken with PET/CT post-treatment to evaluate response. Results: Median age of patients was 49·4 years (minimum age of 32 years and maximum of 68 years). Males were predominant 22 (73·3%). Nasopharynx was the predominant site 16/30 (53·3%). PET/CT changed the overall staging in 40% of the patients (upstaged in 36·7% and downstaged in 3·3%). Gross tumour volume (GTV) of PET/CT was smaller in 23 patients (76·7%) and larger in 5 (16·7%) than the GTV of conventional CT, whereas GTV of lymph nodes of PET/CT was larger in 20 patients (67·7%) and smaller in 4 (13·3%). PET/CT study detected bone metastasis in two nasopharyngeal carcinoma patients and two cases of 2nd primary tumours which were not detected using conventional CT. The Cox-regression model showed that the median standardised uptake volume (SUV) of the initial tumour had been a dependent predictor of death in patients with HNSCC (p-value = 0·033) where the risk of death was 0·725 times among patients with high SUV of the initial tumour. Consequently, the size of GTV of the tumour was significant in the prediction of death (p = 0·018). Conclusions: 18F-FDG-PET/CT is useful for staging, radiotherapy delineation as well as aiding proper decision making, in addition to assessment of treatment response in HNSCC patients.

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