PH-0445 Preliminary results of the Italian Retrospective Study on adjuvant radiotherapy for vulvar cancer

Abstract Background Thyroid lobectomy is recommended with total laryngectomy for laryngeal cancer in the National Comprehensive Cancer Network (‘NCCN’) guidelines. However, it is associated with a 32–89 per cent risk of hypothyroidism, with or without adjuvant radiotherapy. Objective The study aimed to determine whether preserving the whole thyroid, compared to a single lobe, does indeed significantly lower the incidence of hypothyroidism in the setting of total laryngectomy. Method A retrospective study was conducted at Groote Schuur Hospital in Cape Town, South Africa. Results Eighty-four patients met the inclusion criteria. The overall incidence of hypothyroidism was 45.2 per cent. The incidence of hypothyroidism was significantly reduced in patients who underwent thyroid-sparing total laryngectomy compared to hemithyroidectomy (p = 0.037). Adjuvant radiotherapy was associated with a higher incidence of hypothyroidism (p = 0.001). Conclusion Thyroid-preserving laryngectomy should be advocated in carefully selected patients with advanced laryngeal carcinoma, as it reduces the incidence of hypothyroidism.

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HLA-G 14-bp polymorphism: a possible marker of systemic treatment response in psoriasis vulgaris? Preliminary results of a retrospective study

Dermatologic Therapy ◽

10.1111/dth.12140 ◽

2014 ◽

Vol 27 (5) ◽

pp. 284-289 ◽

Cited By ~ 7

Author(s):

Alessandro Borghi ◽

Roberta Rizzo ◽

Monica Corazza ◽

Alberto Maria Bertoldi ◽

Daria Bortolotti ◽

...

Keyword(s):

Retrospective Study ◽

Treatment Response ◽

Psoriasis Vulgaris ◽

Systemic Treatment ◽

Preliminary Results ◽

G 14

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Validation of a nomogram for predicting outcome of vulvar cancer patients, primarily treated by surgery, in Korean population: multicenter retrospective study through Korean Gynecologic Oncology Group (KGOG-1010)

Journal of Gynecologic Oncology ◽

10.3802/jgo.2008.19.3.191 ◽

2008 ◽

Vol 19 (3) ◽

pp. 191 ◽

Cited By ~ 2

Author(s):

Mi-Kyung Kim ◽

Jae Weon Kim ◽

Jong-Min Lee ◽

Nak-Woo Lee ◽

Moon-Seok Cha ◽

...

Keyword(s):

Retrospective Study ◽

Cancer Patients ◽

Vulvar Cancer ◽

Gynecologic Oncology ◽

Korean Population ◽

Gynecologic Oncology Group ◽

Oncology Group ◽

Predicting Outcome

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Adjuvant radiotherapy and local recurrence in vulvar cancer – a subset analysis of the AGO-CaRE-1 study

Gynecologic Oncology ◽

10.1016/j.ygyno.2021.11.004 ◽

2021 ◽

Author(s):

Linn Woelber ◽

Katharina Prieske ◽

Christine zu Eulenburg ◽

Stefanie Corradini ◽

Cordula Petersen ◽

...

Keyword(s):

Local Recurrence ◽

Adjuvant Radiotherapy ◽

Vulvar Cancer ◽

Subset Analysis

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The impact of p16ink4a positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-020-05431-7 ◽

2020 ◽

Vol 301 (3) ◽

pp. 753-759 ◽

Cited By ~ 1

Author(s):

Lisa Gensthaler ◽

Elmar A. Joura ◽

Laia Alemany ◽

Reinhard Horvat ◽

Silvia de Sanjosé ◽

...

Keyword(s):

Retrospective Study ◽

Vulvar Cancer ◽

Disease Specific Survival ◽

The Impact ◽

Disease Free ◽

Disease Specific

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Patterns of treatment failure in patients undergoing adjuvant or definitive radiotherapy for vulvar cancer

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2019-000223 ◽

2019 ◽

Vol 29 (5) ◽

pp. 857-862

Author(s):

Christina Steen Vorbeck ◽

Anuja Jhingran ◽

Revathy B Iyer ◽

Annika Loft ◽

Ann Klopp ◽

...

Keyword(s):

Adjuvant Radiotherapy ◽

Clinical Decision Making ◽

Vulvar Cancer ◽

Recurrent Disease ◽

Treatment Strategies ◽

High Dose ◽

Definitive Radiotherapy ◽

Failure Patterns ◽

Gynecology And Obstetrics ◽

Dose Planning

ObjectivesKnowledge of the detailed pattern of failure can be useful background knowledge in clinical decision making and potentially drive the development of new treatment strategies by increasing radiotherapy dose prescription to high-risk sub-regions of the target. Here, we analyze patterns of recurrence in patients with vulvar cancer treated with radiotherapy according to original planning target volumes and radiation dose delivered.MethodsWe analyzed dose-planning and post-treatment recurrence scans from patients with vulvar cancer treated at two institutions from January 2009 through October 2014. We delineated the recurrences and merged the dose-planning and recurrence scans for each patient by using deformable co-registration. We estimated the center of each recurrence on the merged scans with the goal of relating them to the original dose plan.ResultsWe evaluated 157 patients who received radiotherapy for vulvar cancer. Median age was 68 years (range 29–91). Patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA-IVB were included. Twenty-nine patients had recurrent disease; 156 patients had squamous cell carcinoma and one patient had adenosquamous carcinoma of the vulva. Among the 157 patients, 37 patients with recurrent disease had recurrence scans available for review, for a total of 80 recurrence sites; 53% of the recurrences were located in the region to which the highest dose (60–70 Gy) had been prescribed. Patients who received definitive radiotherapy developed failure primarily in the high-dose region (80.5%), whereas patients who received adjuvant radiotherapy had a more scattered failure pattern (p<0.0001). Among the latter group, 29.5% failed in the high-dose region.ConclusionsPatients who received definitive versus adjuvant radiotherapy had different failure patterns, indicating that separate approaches are needed to improve both adjuvant and definitive radiotherapy for vulvar cancer.

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