PO-1765 Markerless 3D tumor tracking during single-fraction free-breathing flattening-filter-free lung SBRT

2021 ◽  
Vol 161 ◽  
pp. S1492-S1493
Author(s):  
I. Remmerts de Vries ◽  
M. Dahele ◽  
H. Mostafavi ◽  
B. Slotman ◽  
W. Verbakel
2012 ◽  
Vol 103 ◽  
pp. S592
Author(s):  
P. Saldaña ◽  
I. Modolell ◽  
F. Pino ◽  
S. Llacer

Author(s):  
M. Rao ◽  
J. Ye ◽  
J. Spiegel ◽  
R. Takamiya ◽  
V.K. Mehta ◽  
...  

2015 ◽  
Vol 42 (6Part18) ◽  
pp. 3423-3423 ◽  
Author(s):  
L Ouyang ◽  
H Lee ◽  
A Pompos ◽  
Y Yan ◽  
S Jiang ◽  
...  

Author(s):  
Oleg N. Vassiliev ◽  
Christine B. Peterson ◽  
Joe Y. Chang ◽  
Radhe Mohan

Abstract Aim: Previous studies showed that replacing conventional flattened beams (FF) with flattening filter-free (FFF) beams improves the therapeutic ratio in lung stereotactic body radiation therapy (SBRT), but these findings could have been impacted by dose calculation uncertainties caused by the heterogeneity of the thoracic anatomy and by respiratory motion, which were particularly high for target coverage. In this study, we minimised such uncertainties by calculating doses using high-spatial-resolution Monte Carlo and four-dimensional computed tomography (4DCT) images. We aimed to evaluate more reliably the benefits of using FFF beams for lung SBRT. Materials and methods: For a cohort of 15 patients with early-stage lung cancer that we investigated in a previous treatment planning study, we recalculated dose distributions with Monte Carlo using 4DCT images. This included 15 FF and 15 FFF treatment plans. Results: Compared to Monte Carlo, the treatment planning system (TPS) over-predicted doses in low-dose regions of the planning target volume (PTV). For most patients, replacing FF beams with FFF beams improved target coverage, tumour control, and uncomplicated tumour control probabilities. Conclusions: Monte Carlo tends to reveal deficiencies in target coverage compared to coverage predicted by the TPS. Our data support previously reported benefits of using FFF beams for lung SBRT.


2018 ◽  
Vol 24 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Karthick Raj Mani ◽  
Md. Anisuzzaman Bhuiyan ◽  
Md. Mahbub Alam ◽  
Sharif Ahmed ◽  
Mostafa Aziz Sumon ◽  
...  

Abstract Aim: To compare the dosimetric advantage of stereotactic body radiotherapy (SBRT) for localized lung tumor between deep inspiration breath hold technique and free breathing technique. Materials and methods: We retrospectively included ten previously treated lung tumor patients in this dosimetric study. All the ten patients underwent CT simulation using 4D-CT free breathing (FB) and deep inspiration breath hold (DIBH) techniques. Plans were created using three coplanar full modulated arc using 6 MV flattening filter free (FFF) bream with a dose rate of 1400 MU/min. Same dose constraints for the target and the critical structures for a particular patient were used during the plan optimization process in DIBH and FB datasets. We intend to deliver 50 Gy in 5 fractions for all the patients. For standardization, all the plans were normalized at target mean of the planning target volume (PTV). Doses to the critical structures and targets were recorded from the dose volume histogram for evaluation. Results: The mean right and left lung volumes were inflated by 1.55 and 1.60 times in DIBH scans compared to the FB scans. The mean internal target volume (ITV) increased in the FB datasets by 1.45 times compared to the DIBH data sets. The mean dose followed by standard deviation (x̄ ± σx̄) of ipsilateral lung for DIBH-SBRT and FB-SBRT plans were 7.48 ± 3.57 (Gy) and 10.23 ± 4.58 (Gy) respectively, with a mean reduction of 36.84% in DIBH-SBRT plans. Ipsilateral lung were reduced to 36.84% in DIBH plans compared to FB plans. Conclusion: Significant dose reduction in ipsilateral lung due to the lung inflation and target motion restriction in DIBH-SBRT plans were observed compare to FB-SBRT. DIBH-SBRT plans demonstrate superior dose reduction to the normal tissues and other critical structures.


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