59 VX-950, a novel HCV protease inhibitor, retains potency against BILN-2061 resitant replicon cells: Computational analysis indicates that resistance develops via different mechanisms

2004 ◽  
Vol 40 ◽  
pp. 21
Author(s):  
C. Lin ◽  
K. Lin ◽  
Y.P. Luong ◽  
B.G. Rao ◽  
Y.Y. Wei ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Computational Analysis ◽  
Hcv Protease

Discovery and Development of the HCV Protease Inhibitor TMC435

2011 ◽  
pp. 273-286
Author(s):  
Pierre Raboisson ◽  
Gregory Fanning ◽  
Herman de Kock ◽  
Åsa Rosenquist ◽  
René Verloes ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Hcv Protease

scholarly journals Clinical impact of pharmacokinetic interactions between the HCV protease inhibitor simeprevir and frequently used concomitant medications

2018 ◽  
Vol 84 (5) ◽  
pp. 961-971 ◽  
Author(s):  
Fiona Marra ◽  
Christoph Höner zu Siederdissen ◽  
Saye Khoo ◽  
David Back ◽  
Michael Schlag ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Clinical Impact ◽  
Pharmacokinetic Interactions ◽  
Hcv Protease ◽  
Concomitant Medications

87 MOLECULAR CHARACTERIZATION OF HCV RESISTANCE TO TELAPREVIR, A NOVEL, POTENT HCV PROTEASE INHIBITOR

2009 ◽  
Vol 50 ◽  
pp. S36
Author(s):  
S. Chevaliez ◽  
A. Ahmed-Belkacem ◽  
L. Barbotte ◽  
A. Soulier ◽  
D. Bartels ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Molecular Characterization ◽  
Hcv Protease

scholarly journals Lack of a clinically significant drug-drug interaction in healthy volunteers between the HCV protease inhibitor boceprevir and the proton pump inhibitor omeprazole

2013 ◽  
Vol 68 (6) ◽  
pp. 1415-1422 ◽  
Author(s):  
C. T. M. M. de Kanter ◽  
A. P. H. Colbers ◽  
M. I. Blonk ◽  
C. P. W. G. M. Verweij-van Wissen ◽  
B. J. J. W. Schouwenberg ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitor ◽  
Protease Inhibitor ◽  
Healthy Volunteers ◽  
Proton Pump ◽  
Hcv Protease ◽  
Drug Drug Interaction ◽  
Clinically Significant

Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro

2007 ◽  
Vol 73 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Gennadiy Koev ◽  
Tatyana Dekhtyar ◽  
Lixin Han ◽  
Ping Yan ◽  
Teresa I. Ng ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Protease
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