Faculty of 1000 evaluation for Lack of a clinically significant drug-drug interaction in healthy volunteers between the HCV protease inhibitor boceprevir and the HIV integrase inhibitor raltegravir.

2013 ◽  
Author(s):  
Glenn Tillotson
Keyword(s):  
Drug Interaction ◽  
Protease Inhibitor ◽  
Healthy Volunteers ◽  
Integrase Inhibitor ◽  
Hiv Integrase ◽  
Hcv Protease ◽  
Drug Drug Interaction ◽  
Clinically Significant

scholarly journals Lack of a clinically significant drug-drug interaction in healthy volunteers between the HCV protease inhibitor boceprevir and the proton pump inhibitor omeprazole

2013 ◽  
Vol 68 (6) ◽  
pp. 1415-1422 ◽  
Author(s):  
C. T. M. M. de Kanter ◽  
A. P. H. Colbers ◽  
M. I. Blonk ◽  
C. P. W. G. M. Verweij-van Wissen ◽  
B. J. J. W. Schouwenberg ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Proton Pump Inhibitor ◽  
Protease Inhibitor ◽  
Healthy Volunteers ◽  
Proton Pump ◽  
Hcv Protease ◽  
Drug Drug Interaction ◽  
Clinically Significant

Antiretroviral concentrations in the presence and absence of valproic acid

2020 ◽  
Vol 75 (7) ◽  
pp. 1969-1971
Author(s):  
A Calcagno ◽  
J Cusato ◽  
M Ferrara ◽  
A De Nicolò ◽  
A Lazzaro ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Drug Interaction ◽  
Plasma Concentrations ◽  
Integrase Inhibitor ◽  
Major Effect ◽  
Therapeutic Drug ◽  
Hiv Integrase ◽  
Drug Drug Interaction ◽  
Underlying Mechanisms ◽  
Protein Displacement

Abstract Objectives An unexpected drug–drug interaction has been recently reported between dolutegravir, an HIV integrase inhibitor, and valproic acid. Despite there being several potential underlying mechanisms, plasma protein displacement has been suggested. The aim of this study was to assess plasma concentrations of several antiretrovirals when administered with or without valproic acid. Methods We performed a therapeutic drug monitoring registry analysis and identified patients concomitantly taking antiretrovirals and valproic acid and without clinical affecting conditions or interacting drugs. Results One hundred and thirty-four patients were identified. Median (IQR) age and BMI were 49.7 years (45–56) and 23.4 kg/m2 (20.8–26.3) and 78 were male (58.2%). Despite small groups, we observed no major effect on antiretroviral exposure, even when considering highly protein-bound compounds (such as etravirine), with the exception of dolutegravir trough concentrations [median (IQR) = 132 ng/mL (62–227) in individuals on valproic acid versus 760 ng/mL (333–1407) in those not receiving valproic acid]. Conclusions Valproic acid does not have a major effect on antiretrovirals other than dolutegravir. The mechanism of this unexpected drug–drug interaction may be the combination of protein displacement, reduced absorption and CYP3A4 induction.

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers

2018 ◽  
Vol 74 (12) ◽  
pp. 1605-1613 ◽  
Author(s):  
Soyoung Lee ◽  
Yun Kim ◽  
Janice Ji Sung Lee ◽  
Guangjin Im ◽  
Joo-Youn Cho ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug

scholarly journals Drug-Drug Interaction Analysis of Pyronaridine/Artesunate and Ritonavir in Healthy Volunteers

2012 ◽  
Vol 86 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Carrie A. Morris ◽  
Luis Lopez-Lazaro ◽  
Donald Jung ◽  
Janthima Methaneethorn ◽  
Stephan Duparc ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Interaction Analysis ◽  
Drug Drug Interaction

scholarly journals Concomitant Intake of Coca‐Cola to Manage the Drug–Drug Interaction Between Velpatasvir and Omeprazole Studied in Healthy Volunteers

2019 ◽  
Vol 106 (5) ◽  
pp. 1093-1098 ◽  
Author(s):  
Minou Seyen ◽  
Angela Colbers ◽  
Evertine J. Abbink ◽  
Joost P.H. Drenth ◽  
David M. Burger
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Drug Drug Interaction
Sign in / Sign up

Export Citation Format

Share Document