The Journey to the Discovery of Boceprevir: An NS3–NS4 HCV Protease Inhibitor for the Treatment of Chronic Hepatitis C

64 SAFETY OF THE HCV PROTEASE INHIBITOR TMC435350 IN HEALTHY VOLUNTEERS AND SAFETY AND ACTIVITY IN CHRONIC HEPATITIS C INFECTED INDIVIDUALS: A PHASE I STUDY

Journal of Hepatology ◽

10.1016/s0168-8278(08)60066-5 ◽

2008 ◽

Vol 48 ◽

pp. S28-S29 ◽

Cited By ~ 11

Author(s):

H. Reesink ◽

R. Verloes ◽

K. Abou Farha ◽

A. Van Vliet ◽

C. Weegink ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Protease Inhibitor ◽

Phase I ◽

Healthy Volunteers ◽

Chronic Hepatitis C ◽

Phase I Study ◽

Hcv Protease

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283 HCV PROTEASE INHIBITOR RESTORES INSULIN SENSITIVITY IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS

Journal of Hepatology ◽

10.1016/s0168-8278(10)60285-1 ◽

2010 ◽

Vol 52 ◽

pp. S118-S119

Author(s):

R. Moucari ◽

N. Forestier ◽

D. Larrey ◽

D. Guyader ◽

P. Couzigou ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Insulin Sensitivity ◽

Protease Inhibitor ◽

Chronic Hepatitis C ◽

Genotype 1 ◽

Hcv Protease ◽

Chronic Hepatitis C Patients

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Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor

Antiviral Therapy ◽

10.3851/imp2078 ◽

2012 ◽

Vol 17 (4) ◽

pp. 633-642 ◽

Cited By ~ 4

Author(s):

Joep de Bruijne ◽

Andre van Vliet ◽

Christine J Weegink ◽

Włodzimierz Mazur ◽

Alicja Wiercinska-Drapało ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Protease Inhibitor ◽

Chronic Hepatitis C ◽

Viral Rna ◽

Rapid Decline ◽

Once Daily ◽

Hcv Protease ◽

Chronic Hepatitis C Patients

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Development of autoantibodies against “rings and rods”-associated IMPDH2 in chronic hepatitis C genotype 1 infection during protease inhibitor based triple therapy in a “real life” cohort

Zeitschrift für Gastroenterologie ◽

10.1055/s-0036-1597391 ◽

2016 ◽

Vol 54 (12) ◽

pp. 1343-1404

Author(s):

W Dammermann ◽

S Polywka ◽

I Dettmann ◽

S Mindorf ◽

L Komorowski ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Protease Inhibitor ◽

Triple Therapy ◽

Chronic Hepatitis C ◽

Real Life ◽

Genotype 1

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Limited effectiveness and safety profile of protease inhibitor-based triple therapy against chronic hepatitis C in a real-world cohort with a high proportion of advanced liver disease

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0000000000000121 ◽

2014 ◽

Vol 26 (8) ◽

pp. 836-845 ◽

Cited By ~ 20

Author(s):

Benjamin Maasoumy ◽

Kerstin Port ◽

Katja Deterding ◽

Christoph Höner zu Siederdissen ◽

Antoaneta A. Markova ◽

...

Keyword(s):

Chronic Hepatitis ◽

Liver Disease ◽

Hepatitis C ◽

Protease Inhibitor ◽

Triple Therapy ◽

Chronic Hepatitis C ◽

Real World ◽

Safety Profile ◽

Advanced Liver Disease ◽

Limited Effectiveness

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Induction of interleukin-6 by interferon alfa and its abrogation by a serine protease inhibitor in patients with chronic hepatitis C

Hepatology ◽

10.1002/hep.510230403 ◽

1996 ◽

Vol 23 (4) ◽

pp. 669-675 ◽

Cited By ~ 21

Author(s):

N Ito ◽

S Kawata ◽

S Tamura ◽

S Kiso ◽

H Tsushima ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Protease Inhibitor ◽

Serine Protease ◽

Chronic Hepatitis C ◽

Interleukin 6 ◽

Serine Protease Inhibitor ◽

Interferon Alfa

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294 Safety and antiviral effect of BILN 2061, a novel HCV serine protease inhibitor, after oral treatment over 2 days in patients with chronic hepatitis C, genotype 1, and liver cirrhosis

Hepatology ◽

10.1016/s0270-9139(03)80337-3 ◽

2003 ◽

Vol 38 ◽

pp. 297-297 ◽

Cited By ~ 3

Author(s):

H WEDEMEYER ◽

A ERHARDT ◽

W SCHMIEGEL ◽

H HINRICHSEN ◽

R CHAVES ◽

...

Keyword(s):

Liver Cirrhosis ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Protease Inhibitor ◽

Serine Protease ◽

Chronic Hepatitis C ◽

Oral Treatment ◽

Antiviral Effect ◽

Serine Protease Inhibitor ◽

Genotype 1

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Curing Chronic Hepatitis C: A Cost Comparison of the Combination Simeprevir Plus Sofosbuvir vs. Protease-Inhibitor-Based Triple Therapy

Annals of Hepatology ◽

10.5604/01.3001.0009.8591 ◽

2017 ◽

Vol 16 (3) ◽

pp. 366-374 ◽

Cited By ~ 2

Author(s):

Jacob A. Langness ◽

David Tabano ◽

Amanda Wieland ◽

Sarah Tise ◽

Lindsay Pratt ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Protease Inhibitor ◽

Triple Therapy ◽

Chronic Hepatitis C ◽

Cost Comparison

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Danoprevir, an HCV NS3/4A protease inhibitor, improves insulin sensitivity in patients with genotype 1 chronic hepatitis C

Gut ◽

10.1136/gut.2010.219089 ◽

2010 ◽

Vol 59 (12) ◽

pp. 1694-1698 ◽

Cited By ~ 51

Author(s):

Rami Moucari ◽

Nicole Forestier ◽

Dominique Larrey ◽

Dominique Guyader ◽

Patrice Couzigou ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Insulin Sensitivity ◽

Protease Inhibitor ◽

Chronic Hepatitis C ◽

Genotype 1

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Glomerular filtration rate change during chronic hepatitis C treatment with Sofosbuvir/Ledipasvir in HCV/HIV Coinfected patients treated with Tenofovir and a boosted protease inhibitor: an observational prospective study

BMC Infectious Diseases ◽

10.1186/s12879-018-3278-3 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 3

Author(s):

Cristina Aurora São Pedro Soeiro ◽

Celina Andreia Melo Gonçalves ◽

Marta Sofia Correia Marques ◽

Maria Josefina Vazquez Méndez ◽

Ana Paula Ribeiro Almeida Tavares ◽

...

Keyword(s):

Chronic Hepatitis ◽

Glomerular Filtration Rate ◽

Hepatitis C ◽

Protease Inhibitor ◽

Prospective Study ◽

Glomerular Filtration ◽

Chronic Hepatitis C ◽

Filtration Rate ◽

Rate Change ◽

Hepatitis C Treatment

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