306 Possible role of BSEP-mediated bile acid transport inhibition by progesterone metabolites in the aetiopathogenesis of intrahepatic cholestasis of pregnancy

Background: Maternal, fetal, and neonatal outcomes in parturients with intrahepatic cholestasis of pregnancy (ICP) have been retrospectively documented. We aimed to present pregnancy outcomes of parturients with ICP who underwent delivery. The study was conducted during a 1-year period in a tertiary care centre.Methods: Data from 1 January to 31 December 2017 were collected to identify parturients with ICP.Results: Almost 3/4th of births came to a vaginal delivery (76.74%) and only 10 parturients had cesarean delivery. 4 of 10 parturients underwent nonelective cesarean section, while 6 had elective cesarean delivery. 15.15 % vaginal deliveries were instrumental. The most common indications for emergency LSCS and instrumental deliveries was fetal distress followed by failure to progress of labour. Most births occurred at or after 37 weeks of gestation (65%). Regarding neonatal outcomes in terms of birth weight and Apgar scores at 1 and 5 min, they were positive, as well. None of the babies had Apgar score < 7 at 5 minutes. No case of perinatal death was observed.Conclusions: Although the results were generally positive, larger studies need to be conducted to evaluate the maternal and fetal outcomes in ICP and correlation with serum bile acid levels.

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Role of serum organic solute transporter alpha/beta and sodium taurocholate cotransporting polypeptide in intrahepatic cholestasis of pregnancy

Ginekologia Polska ◽

10.5603/gp.a2021.0063 ◽

2021 ◽

Author(s):

Kader İrak ◽

Mehmet Bayram ◽

Sami Cifci ◽

Zuat Acar ◽

Cemal Kazezoğlu ◽

...

Keyword(s):

Intrahepatic Cholestasis ◽

Sodium Taurocholate ◽

Intrahepatic Cholestasis Of Pregnancy ◽

Organic Solute Transporter ◽

Organic Solute ◽

Alpha Beta ◽

Cholestasis Of Pregnancy ◽

Solute Transporter

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The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy

Acta Biochimica Polonica ◽

10.18388/abp.2020_5841 ◽

2021 ◽

Author(s):

Wojciech Jelski ◽

Joanna Piechota ◽

Karolina Orywal ◽

Barbara Mroczko

Keyword(s):

Bile Acid ◽

Alcohol Dehydrogenase ◽

Bile Acids ◽

Intrahepatic Cholestasis ◽

Total Bile Acid ◽

Intrahepatic Cholestasis Of Pregnancy ◽

Third Trimester ◽

Total Bile Acids ◽

Adh Activity ◽

Cholestasis Of Pregnancy

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is the liver disorder in the second or early third trimester of pregnancy. It is characterized by pruritus with increased serum bile acids concentration and other liver function tests. ICP is connected with increased risk of fetal mortality, but is unfortunately detected quite late. Therefore, it is important to recognize the disease in its early stages. We aimed to investigate the serum alcohol dehydrogenase (ADH) activity and compare it with the concentration of total bile acid (TBA) in women with ICP. Methods: Serum samples were taken for routine investigation from 80 pregnancies with ICP in the second or third trimester of pregnancy and from 80 healthy pregnant women in the same time of pregnancy. For measurement of class I activity we used the spectrofluorometric methods. The total ADH activitiy was measured by the photometric method. Results: The analysis of results shows a statistically significant increase in the activity of ADH I and ADH total (about 60% and 41.3%, respectively). Activity of ADH I well correlated with aminotransferases (alanine ALT and aspartate AST) and total bile acids (TBA) concentration. The total ADH activity was also positively correlated with ALT, AST and total bile acids. Conclusion: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cell destruction during this disease and is comparable with the value of other markers.

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