Transcriptional responses of the vasopressin and corticotropin-releasing hormone genes to acute and repeated intraperitoneal hypertonic saline injection in rats

1999 ◽  
Vol 68 (1-2) ◽  
pp. 129-140 ◽  
Author(s):  
Xin-Ming Ma ◽  
Greti Aguilera
Keyword(s):  
Hypertonic Saline ◽  
Saline Injection ◽  
Corticotropin Releasing Hormone ◽  
Transcriptional Responses ◽  
Releasing Hormone ◽  
Hypertonic Saline Injection

Increased heat-escape/cold-seeking behavior following hypertonic saline injection in rats

2001 ◽  
Vol 280 (4) ◽  
pp. R1031-R1036 ◽  
Author(s):  
Kei Nagashima ◽  
Sadamu Nakai ◽  
Masahiro Konishi ◽  
Liu Su ◽  
Kazuyuki Kanosue
Keyword(s):  
Osmotic Stress ◽  
Hypertonic Saline ◽  
Core Temperature ◽  
Defense Mechanisms ◽  
Specific Area ◽  
Saline Injection ◽  
Lower Baseline ◽  
Seeking Behavior ◽  
Hypertonic Saline Injection

We examined the effect of hypertonic saline injection on heat-escape/cold-seeking behavior in desalivated rats. Rats were exposed to 40°C heat after normal (154 mM NaCl, control) or hypertonic saline (2,500 mM NaCl) injection (1 ml/100 g body wt). The rats received a 0°C air for 30 s when they entered a specific area in an experimental box. Core temperature (Tc) surpassed 40°C in both conditions when 0°C air was not available. Hypertonic saline injection produced a lower baseline Tcthan control [36.9 ± 0.2 and 37.9 ± 0.2°C (means ± SE), P < 0.05] and a greater number of 0°C air rewards during the 2-h heat with lower Tc at the end (48 ± 1 and 34 ± 2, 37.6 ± 0.1, and 37.3 ± 0.1°C in the control and hypertonic saline injection trial, respectively, P < 0.05, n = 6). However, Tc was similar (37.7 ± 0.2 and 37.6 ± 0.4°C in the control and hypertonic saline injection trial, n = 5) when 0°C air was automatically and intermittently (35 times) given during the heat. Rats augment heat-defense mechanisms in response to osmotic stress by lowering the baseline Tc and increasing heat-escape/cold-seeking behavior.

Use of hypertonic saline injection in trauma

2010 ◽  
Vol 67 (22) ◽  
pp. 1920-1928 ◽  
Author(s):  
Asad E. Patanwala ◽  
Albert Amini ◽  
Brian L. Erstad
Keyword(s):  
Hypertonic Saline ◽  
Saline Injection ◽  
Hypertonic Saline Injection
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